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Ritchie Ho

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Principal Investigator

Cedars-Sinai Medical Center

United States

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Comparative genomic approaches to improve iPSC-derived motor neuron models of ALS

Open Date: 2017-09-01

Close Date: 2019-08-31

Articles (12)

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2025

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Collaborators (11)

Ernest Fraenkel

Massachusetts Institute of Technology

UNITED STATES

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Heather Himburg

Associate Professor

Medical College of Wisconsin

UNITED STATES

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Sanjeev Kumar

Nephrologist-Scientist

Cedars-Sinai Medical Center

UNITED STATES

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Arun Sharma

Assistant Professor

Cedars-Sinai Medical Center

UNITED STATES

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Wenting Guo

INSERM associate professor

INSERM

FRANCE

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Philip Van Damme

University Hospitals Leuven

BELGIUM

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Alberto Catanese

Director

Université Paris Descartes

FRANCE

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Julian Großkreutz

Chair of Precision Neurology

University of Lübeck

GERMANY

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Medhanie A. Mulaw

Professor (Molecular Oncology and Functional Genomics)

Universität Ulm

GERMANY

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Francis Impens

Associate Professor

Ghent University

BELGIUM

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Oleg A. Karpov

University of Edinburgh

UNITED KINGDOM

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Ritchie Ho

Research Interests

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Recent Grants

Articles (12)

Targeted Proteomics upon Treatment with Tofersen Identifies Novel Response Markers for Superoxide Dismutase 1-Linked Amyotrophic Lateral Sclerosis.

The myokine FGF21 associates with enhanced survival in ALS and mitigates stress-induced cytotoxicity.

Multi-lineage heart-chip models drug cardiotoxicity and enhances maturation of human stem cell-derived cardiovascular cells

Heterozygous knockout of Synaptotagmin13 phenocopies ALS features and TP53 activation in human motor neurons

Disease related changes in ATAC-seq of iPSC-derived motor neuron lines from ALS patients and controls.

Inhibition of Ephrin B2 Reverse Signaling Abolishes Multiple Myeloma Pathogenesis

Delineating sex-dependent and anatomic decline of motor functions in the SOD1G93A mouse model of amyotrophic lateral sclerosis.

Multiomics and machine-learning identify novel transcriptional and mutational signatures in amyotrophic lateral sclerosis.

CRISPR/Cas9 screen in human iPSC-derived cortical neurons identifies NEK6 as a novel disease modifier of C9orf72 poly(PR) toxicity

Large-scale differentiation of iPSC-derived motor neurons from ALS and control subjects.

Human iPSC-derived neural progenitor cells secreting GDNF provide protection in rodent models of ALS and retinal degeneration

NeuroLINCS Proteomics: Defining human-derived iPSC proteomes and protein signatures of pluripotency

Collaborators (11)

Ernest Fraenkel

Heather Himburg

Sanjeev Kumar

Arun Sharma

Wenting Guo

Philip Van Damme

Alberto Catanese

Julian Großkreutz

Medhanie A. Mulaw

Francis Impens

Oleg A. Karpov

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