Robert Kleszcz

Assistant Professor

Poznan University of Medical Sciences

Poland

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Research Interests

Cell Biology

30%

Biochemistry

50%

Cancer Biology

60%

Phytochemical

50%

Cancer Therapy

40%

Kinase Biology

30%

Epithelial-mesenchymal Transition

30%

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Recent Grants

Grant: Close

Ocena synergistycznego działania przeciwnowotworowego równoczesnej inhibicji ścieżki sygnałowej Wnt i metabolizmu energetycznego glukozy w komórkach raka języka,

Open Date: 2019-11-22

Close Date: 2020-11-21

Grant: Close

Open Research Biopharmaceutical Internships Support

Open Date: 2018-03-01

Close Date: 2022-02-28

Articles13

Anti-Aging Properties of Chitosan-Based Hydrogels Rich in Bilberry Fruit Extract

Article Link

Year:

2024

Combinations of PRI-724 Wnt/β-Catenin Pathway Inhibitor with Vismodegib, Erlotinib, or HS-173 Synergistically Inhibit Head and Neck Squamous Cancer Cells

Article Link

Year:

2023

PRI-724 and IWP-O1 Wnt Signaling Pathway Inhibitors Modulate the Expression of Glycolytic Enzymes in Tongue Cancer Cell Lines

Article Link

Year:

2023

Advantages of the Combinatorial Molecular Targeted Therapy of Head and Neck Cancer—A Step before Anakoinosis-Based Personalized Treatment

Article Link

Year:

2023

Indomethacin and Diclofenac Hybrids with Oleanolic Acid Oximes Modulate Key Signaling Pathways in Pancreatic Cancer Cells

Article Link

Year:

2022

Lichen Secondary Metabolites Inhibit the Wnt/β-Catenin Pathway in Glioblastoma Cells and Improve the Anticancer Effects of Temozolomide

Article Link

Year:

2022

The Wnt Signaling Pathway Inhibitors Improve the Therapeutic Activity of Glycolysis Modulators against Tongue Cancer Cells

Article Link

Year:

2022

The combinatorial inhibition of Wnt signaling and Akt kinase is beneficial for reducing the survival and glycolytic activity of tongue cancer cells

Article Link

Year:

2022

The synthesis of novel thioderivative chalcones and their influence on NF-κB, STAT3 and NRF2 signaling pathways in colorectal cancer cells

Article Link

Year:

2022

Comparison of the Impact of Xanthohumol and Phenethyl Isothiocyanate and Their Combination on Nrf2 and NF-κB Pathways in HepG2 Cells In Vitro and Tumor Burden In Vivo

Article Link

Year:

2021

Lichen-Derived Depsides and Depsidones Modulate the Nrf2, NF-κB and STAT3 Signaling Pathways in Colorectal Cancer Cells

Article Link

Year:

2021

Attenuation of Pancreatic Cancer In Vitro and In Vivo via Modulation of Nrf2 and NF-κB Signaling Pathways by Natural Compounds

Article Link

Year:

2021

Sodium Butyrate Enhances Curcuminoids Permeability through the Blood-Brain Barrier, Restores Wnt/β-Catenin Pathway Antagonists Gene Expression and Reduces the Viability of Glioblastoma Cells

Article Link

Year:

2021

Collaborators9

Malgorzata Kucinska

Poznan University of Medical Sciences

POLAND

Judyta Cielecka-Piontek

Poznan University of Medical Sciences

POLAND

Marcin Rucinski

professor

Medical University

POLAND

Marta Cykowiak

Poznan University of Medical Sciences

POLAND

Elżbieta Studzińska-Sroka

Poznan University of Medical Sciences

POLAND

Jaroslaw Paluszczak

Associate Professor

Poznan University of Medical Sciences

POLAND

Wanda Baer-Dubowska

Professor

Poznan University of Medical Sciences

POLAND

Violetta Krajka-Kuźniak

Poznan University of Medical Sciences

POLAND

Hanna Szaefer

Poznan University of Medical Sciences

POLAND

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Robert Kleszcz

Assistant Professor

How do I reach out?

Contact this professor

Research Interests

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Recent Grants

Articles13

Anti-Aging Properties of Chitosan-Based Hydrogels Rich in Bilberry Fruit Extract

Combinations of PRI-724 Wnt/β-Catenin Pathway Inhibitor with Vismodegib, Erlotinib, or HS-173 Synergistically Inhibit Head and Neck Squamous Cancer Cells

PRI-724 and IWP-O1 Wnt Signaling Pathway Inhibitors Modulate the Expression of Glycolytic Enzymes in Tongue Cancer Cell Lines

Advantages of the Combinatorial Molecular Targeted Therapy of Head and Neck Cancer—A Step before Anakoinosis-Based Personalized Treatment

Indomethacin and Diclofenac Hybrids with Oleanolic Acid Oximes Modulate Key Signaling Pathways in Pancreatic Cancer Cells

Lichen Secondary Metabolites Inhibit the Wnt/&beta;-Catenin Pathway in Glioblastoma Cells and Improve the Anticancer Effects of Temozolomide

The Wnt Signaling Pathway Inhibitors Improve the Therapeutic Activity of Glycolysis Modulators against Tongue Cancer Cells

The combinatorial inhibition of Wnt signaling and Akt kinase is beneficial for reducing the survival and glycolytic activity of tongue cancer cells

The synthesis of novel thioderivative chalcones and their influence on NF-κB, STAT3 and NRF2 signaling pathways in colorectal cancer cells

Comparison of the Impact of Xanthohumol and Phenethyl Isothiocyanate and Their Combination on Nrf2 and NF-κB Pathways in HepG2 Cells In Vitro and Tumor Burden In Vivo

Lichen-Derived Depsides and Depsidones Modulate the Nrf2, NF-κB and STAT3 Signaling Pathways in Colorectal Cancer Cells

Attenuation of Pancreatic Cancer In Vitro and In Vivo via Modulation of Nrf2 and NF-&kappa;B Signaling Pathways by Natural Compounds

Sodium Butyrate Enhances Curcuminoids Permeability through the Blood-Brain Barrier, Restores Wnt/β-Catenin Pathway Antagonists Gene Expression and Reduces the Viability of Glioblastoma Cells

Collaborators9

Malgorzata Kucinska

Judyta Cielecka-Piontek

Marcin Rucinski

Marta Cykowiak

Elżbieta Studzińska-Sroka

Jaroslaw Paluszczak

Wanda Baer-Dubowska

Violetta Krajka-Kuźniak

Hanna Szaefer

How do I reach out?

Lichen Secondary Metabolites Inhibit the Wnt/β-Catenin Pathway in Glioblastoma Cells and Improve the Anticancer Effects of Temozolomide

Attenuation of Pancreatic Cancer In Vitro and In Vivo via Modulation of Nrf2 and NF-κB Signaling Pathways by Natural Compounds