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Robert Landsiedel

Germany

Research Interests

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Professors in Germany

Articles (28)

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Collaborators (2)

Sylvia Escher

Division Director Safety Assessment and Toxicology; HEad of Department In Silico Toxicology

Fraunhofer-Gesellschaft

GERMANY

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Vera Ritz

Head of Department

Federal Institute for Risk Assessment

GERMANY

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Robert Landsiedel

Research Interests

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Articles (28)

Dermal absorption of 4,4’-methylene diphenyl diisocyanate (MDI) using human skin preparations

Technical challenges of testing polymer materials in OECD test guideline methods addressing effects on human health, biotic systems and analytics

Frustra laborare ? Methodological inefficiencies and epistemic limits in toxicological testing

A quantitative definition for poorly soluble particles

Colorimetric Assessment of Deiodinase 1 Activity in Human Liver Microsomes Using the Sandell-Kolthoff Reaction

Combined assessment of transgenic rodent gene mutation and micronuclei formation by benzo[a]pyrene, N-ethyl-N-nitrosourea, 2,4-diaminotoluene and ethyl carbamate

Confidence in new approach methods (NAMs): Ensuring reproducibility, operationalising context-of-use and alignment with decision-making needs

Cytotoxicity across OECD methods is not a single endpoint: context-dependent roles, variability and implications for decision-making

Inclusion of a recovery period after pulse treatment in the primary human lymphocyte micronucleus assay covers potential cell cycle delays without loss of sensitivity

Integrative assessment of endocrine disruption: From in vitro mechanisms to species extrapolation – Highlights of the German Pharma-Tox Summit 2025

Lung retention, distribution and persistence of polymer particles in rats exposed via inhalation

Mutagenicity testing with the in vitro Transgenic Rodent Assay (TGRA): From frequencies to signatures,Mutagenitätsprüfung mit dem in vitro-TGRA: von Frequenzen zu Signaturen

Regulation of chemicals demands assessment of risks rather than identification of hazards only

Test substance preparation determines the tested fraction and the outcome of human health NAMs for poorly-water-soluble (pre)polymers

The In Vitro Transgenic Rodent Assay in Primary MutaMouse Hepatocytes Compared to the Mammalian Cell Gene Mutation Assay Using the HPRT Gene

Thyroxin displacement from single and combined thyroid hormone binding proteins by various test substances

Correction to: Time course of lung retention and toxicity of inhaled particles: short-term exposure to nano-Ceria (Archives of Toxicology, (2014), 88, 11, (2033-2059), 10.1007/s00204-014-1349-9)

Correction: Toxicological inhalation studies in rats to substantiate grouping of zinc oxide nanoforms (Particle and Fibre Toxicology, (2024), 21, 1, (24), 10.1186/s12989-024-00572-y)

Evidence of erythropoiesis rather than direct genotoxicity causing micronucleus induction by a new protoporphyrinogen-oxidase inhibitor

Not yet nixing rabbit eyes from the six: the TTT is not predicting the full range of in vivo eye irritation classifications for agrochemical formulations

Application of high throughput in vitro metabolomics for hepatotoxicity mode of action characterization and mechanistic-anchored point of departure derivation: a case study with nitrofurantoin

Engineered nanomaterials and the microbiome: Implications for human health

Assessment of the Predictivity of DIO1-SK Assay to Investigate DIO1 Inhibition in Human Liver Microsomes

Rapid equilibrium dialysis, ultrafiltration or ultracentrifugation? Evaluation of methods to quantify the unbound fraction of substances in plasma

Toward Realistic Dosimetry <i>In Vitro</i>: Determining Effective Concentrations of Test Substances in Cell Culture and Their Prediction by an <i>In Silico</i> Mass Balance Model

A New Approach Method to Study Thyroid Hormone Disruption: Optimization and Standardization of an Assay to Assess the Inhibition of DIO1 Enzyme in Human Liver Microsomes

The thyroid hormone converting enzyme human deiodinase 1 is inhibited by gold ions from inorganic salts, organic substances, and by small-size nanoparticles

N-vinyl compounds: studies on metabolism, genotoxicity, carcinogenicity

Collaborators (2)

Sylvia Escher

Vera Ritz

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