Roland Friedel

Associate Professor

Icahn School of Medicine at Mount Sinai

United States

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Roland Friedel is an Associate Professor at the Icahn School of Medicine at Mount Sinai in the United States. His research focuses on glioblastoma biology, including the mechanisms of cell invasion and microenvironment interactions, as evidenced by his recent publications on Plexin-B signaling and its implications in both glioma and Alzheimer's disease. Additionally, he explores the roles of hypoxia and circadian rhythms in cellular dynamics and regeneration processes.

Articles (16)

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2025

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2025

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2020

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2020

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2020

Collaborators (9)

Dalia Halawani

Assistant Professor (Research Track)

Icahn School of Medicine at Mount Sinai

UNITED STATES

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Chrystian Junqueira Alves

Assistant Professor

Icahn School of Medicine at Mount Sinai

UNITED STATES

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Caroline C. Friedel

Professor

Ludwig-Maximilians-Universität München

GERMANY

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Hongyan Zou

Professor

Icahn School of Medicine at Mount Sinai

UNITED STATES

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XIANXIAO ZHOU

Icahn School of Medicine at Mount Sinai

UNITED STATES

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Ran Taube

ISRAEL

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Nadejda Tsankova

Professor

Icahn School of Medicine at Mount Sinai

UNITED STATES

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Minghui Wang

Associate Professor

Icahn School of Medicine at Mount Sinai

UNITED STATES

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Guohao Dai

Professor

Northeastern University

UNITED STATES

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Roland Friedel

Research Interests

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Articles (16)

Glioblastoma shift from bulk to infiltrative growth is guided by plexin-B2-mediated microglia alignment in invasive niches

3D Brain Vascular Niche Model Captures Glioblastoma Infiltration, Dormancy, and Gene Signatures.

Generation of Plexin‐B1 Conditional Knockout Mouse With CRISPR/Cas9 Technology

Invasion of glioma cells through confined space requires membrane tension regulation and mechano-electrical coupling via Plexin-B2.

Regulation of cell distancing in peri-plaque glial nets by Plexin-B1 affects glial activation and amyloid compaction in Alzheimer's disease.

Hypoxia drives shared and distinct transcriptomic changes in two invasive glioma stem cell lines.

Circadian clock regulator Bmal1 gates axon regeneration via Tet3 epigenetics in mouse sensory neurons

Hypoxic niches attract and sequester tumor-associated macrophages and cytotoxic T cells and reprogram them for immunosuppression.

Macrophages facilitate peripheral nerve regeneration by organizing regeneration tracks through Plexin-B2.

Plexin-B2 orchestrates collective stem cell dynamics via actomyosin contractility, cytoskeletal tension and adhesion.

Diversified transcriptional responses of myeloid and glial cells in spinal cord injury shaped by HDAC3 activity.

Evolution and diversity of semaphorins and plexins in choanoflagellates.

Plexin-B2 facilitates glioblastoma infiltration by modulating cell biomechanics

BMP5/7 protect dopaminergic neurons in an α -synuclein mouse model of Parkinson's disease.

Teaching an Old Drug New Tricks: Dexamethasone as an In Vivo Inhibitor of Glioblastoma Dispersal.

High-resolution tomographic analysis of in vitro 3D glioblastoma tumor model under long-term drug treatment

Collaborators (9)

Dalia Halawani

Chrystian Junqueira Alves

Caroline C. Friedel

Hongyan Zou

XIANXIAO ZHOU

Ran Taube

Nadejda Tsankova

Minghui Wang

Guohao Dai

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