Rudolf Lucas

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Augusta University Medical College of Georgia

United States

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About

Rudolf Lucas is a Professor at Augusta University Medical College of Georgia in the United States. His research areas focus on acute lung injury, endothelial dysfunction, and the mechanisms of inflammatory responses in various pathologies. Recent articles highlight his work on the protective effects of low desulfated heparin, the role of histone deacetylase inhibitors, and the impact of SARS-CoV-2 on macrophage activity.

Recent Grants

Grant: Close

Dissecting TNF in type 1 diabetes-associated cardiovascular disease

Open Date: 2023-07-01

Close Date: 2026-06-30

Grant: Close

ENaC-α mediates lung fluid clearance and capillary barrier function in pneumonia

Open Date: 2018-07-01

Close Date: 2022-06-01

Grant: Close

Increased pneumonia-associated pulmonary barrier dysfunction in type 2 diabetes

Open Date: 2016-01-01

Close Date: 2018-12-31

Grant: Close

Novel peptide-based strategy to inhibit deleterious TNF signaling in nephrotoxic nephritis

Open Date: 2015-08-01

Close Date: 2018-06-30

Grant: Close

Novel Strategies for prevention of diabetic vascular dysfunction.

Open Date: 2012-09-01

Close Date: 2015-08-31

Articles (18)

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2020

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2020

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2020

Collaborators (7)

Ajay Pandey

Augusta University

UNITED STATES

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Eric J. Belin de Chantemele

Professor

Augusta University Medical College of Georgia

UNITED STATES

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Alexander Verin

Augusta University

UNITED STATES

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Scott Barman

Augusta University

UNITED STATES

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Tohru Fukai

Barbara Schnuck Professor

Augusta University Medical College of Georgia

UNITED STATES

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Pau Martin-Malpartida

Institute for Research in Biomedicine

SPAIN

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Maria J Macias

Professor

Instituciò Catalana de Recerca i Estudis Avancats

SPAIN

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Rudolf Lucas

Research Interests

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About

Recent Grants

Articles (18)

Protective Effect of Low 2-O, 3-O Desulfated Heparin (ODSH) Against LPS-Induced Acute Lung Injury in Mice

The histone deacetylase inhibitor CT-101 flips the switch to fetal hemoglobin expression in sickle cell disease mice

Endothelial ENaC-α Restrains Oxidative Stress in Lung Capillaries in Murine Pneumococcal Pneumonia-associated Acute Lung Injury.

PFKFB3 Connects Glycolytic Metabolism with Endothelial Dysfunction in Human and Rodent Obesity

Mechanisms of pulmonary endothelial barrier dysfunction in acute lung injury and acute respiratory distress syndrome

SARS-CoV-2 Spike Protein Stimulates Macropinocytosis in Murine and Human Macrophages via PKC-NADPH Oxidase Signaling

Zinc-Dependent Histone Deacetylases in Lung Endothelial Pathobiology

Characteristics of inflammatory response and repair after experimental blast lung injury in rats

Impact of Endogenous Pneumococcal Hydrogen Peroxide on the Activity and Release of Pneumolysin

Conformational ensemble of the TNF-derived peptide solnatide in solution

Ex Vivo Pulmonary Oedema after In Vivo Blast-Induced Rat Lung Injury: Time Dependency, Blast Intensity and Beta-2 Adrenergic Receptor Role

Safety and preliminary efficacy of sequential multiple ascending doses of solnatide to treat pulmonary permeability edema in patients with moderate-to-severe ARDS-a randomized, placebo-controlled, double-blind trial.

Mice with a specific deficiency of Pfkfb3 in myeloid cells are protected from hypoxia‐induced pulmonary hypertension

Streptococcus pneumoniae and Its Virulence Factors H2O2 and Pneumolysin Are Potent Mediators of the Acute Chest Syndrome in Sickle Cell Disease

Dual Role of Hydrogen Peroxide As an Oxidant in Pneumococcal Pneumonia

Does the 6-minute walk test in hospitalized COPD patients exclusively correlate with lung function parameters or should psychological factors also be taken into account?

Impact of Bacterial Toxins in the Lungs

Loaded Leukosomes

Collaborators (7)

Ajay Pandey

Eric J. Belin de Chantemele

Alexander Verin

Scott Barman

Tohru Fukai

Pau Martin-Malpartida

Maria J Macias

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