Samir EL Andaloussi

The postdoctoral project is based in the research group of Professor Samir EL Andaloussi at the Department of Laboratory Medicine, Karolinska Institutet , where the team develops advanced technologies for the delivery of proteins, RNAs, and genome-editing systems with a strong focus on extrahepatic delivery. The advertised position centers on the rational design and biological evaluation of oligonucleotide conjugates for targeted delivery to specific organs and tissues in vivo. The successful researcher will work on strategies for delivering cargoes such as ASOs and siRNAs, comparing targeting ligands and conjugation chemistries to build RNA conjugates with improved tissue selectivity and delivery performance. Research in the role spans both in vitro and in vivo work. The project includes characterization of conjugate physicochemical properties, analysis of how those properties affect systemic distribution, and evaluation of biological activity across relevant cell systems and animal models. The postdoc will contribute to methods development and optimization for assessing conjugate performance, as well as comparative studies of organ targeting and biodistribution. The group is internationally recognized for work in nanoparticle engineering, targeted drug delivery, and gene therapy, and is embedded in a broader Department of Laboratory Medicine environment that combines basic, translational, and clinical medicine with collaborations across healthcare, industry, and international academic partners. The position is located in Flemingsberg, offering a research setting with broad expertise and cross-disciplinary interaction within one of the world’s leading medical universities.