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Samir EL Andaloussi
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Postdoctoral Researcher to the Division of Biomolecular and Cellular Medicine Karolinska Institutet in Sweden
Degree Level
Postdoc
Field of study
Molecular Biology
Funding
Available
Deadline
Dec 2, 2026
Country
Sweden
University
Karolinska Institutet
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Keywords
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About this position
The postdoctoral project is based in the research group of Professor Samir EL Andaloussi at the Department of Laboratory Medicine, Karolinska Institutet, where the team develops advanced technologies for the delivery of proteins, RNAs, and genome-editing systems with a strong focus on extrahepatic delivery.
The advertised position centers on the rational design and biological evaluation of oligonucleotide conjugates for targeted delivery to specific organs and tissues in vivo. The successful researcher will work on strategies for delivering cargoes such as ASOs and siRNAs, comparing targeting ligands and conjugation chemistries to build RNA conjugates with improved tissue selectivity and delivery performance.
Research in the role spans both in vitro and in vivo work. The project includes characterization of conjugate physicochemical properties, analysis of how those properties affect systemic distribution, and evaluation of biological activity across relevant cell systems and animal models. The postdoc will contribute to methods development and optimization for assessing conjugate performance, as well as comparative studies of organ targeting and biodistribution.
The group is internationally recognized for work in nanoparticle engineering, targeted drug delivery, and gene therapy, and is embedded in a broader Department of Laboratory Medicine environment that combines basic, translational, and clinical medicine with collaborations across healthcare, industry, and international academic partners. The position is located in Flemingsberg, offering a research setting with broad expertise and cross-disciplinary interaction within one of the world’s leading medical universities.
Funding details
Available
What's required
A PhD or an equivalent foreign degree is required and must be completed by the time of the employment decision. Completion of the doctoral degree within the last three years is an advantage, although earlier completion may be accepted for special reasons. Applicants should have a strong background in oligonucleotide conjugate delivery and in vivo biodistribution studies, extensive hands-on experience with mouse handling and delivery routes such as IV and IP, experience with single- and repeat-dose in vivo studies and tissue harvesting, strong understanding of ethics, animal welfare, and regulatory compliance, proficiency in mammalian cell culture and transient transfections, experience with tissue homogenization and RNA isolation, and quantitative assay skills such as RT-qPCR or oligonucleotide detection methods like dPCR or SplintR. Excellent spoken and written English is essential, along with strong interpersonal skills, independence, attention to detail, documentation, and troubleshooting ability.
How to apply
Prepare the application in English or Swedish with a PhD certificate, complete CV including thesis details, publication list, and a one-page summary of current work. Submit the application through the Varbi recruitment system.
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Professors
Professor at Karolinska Institutet
Sweden
Research Interests
Pharmacy
In Vivo Testing
Cell Culture Techniques
Biomedical Engineering
Biology
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Prepare your application
Review drafts and confirm requirements with the university.