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Samir Parekh

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Director, Center of Excellence for Multiple Myeloma

Icahn School of Medicine at Mount Sinai

United States

Research Interests

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Recent Grants

Grant: Open

Developing Lysine Methyltransferase SETD8 Selective Inhibitors for Treating Multiple Myeloma

Open Date: 2025-06-11

Close Date: 2030-05-31

Grant: Open

Implementation of a qPCR-based assay for the quantification of SARS-CoV-2-specific T cells in immunocompromised patients

Open Date: 2023-09-18

Close Date: 2027-08-31

Grant: Close

Targeting SOX11 in Mantle Cell Lymphoma

Open Date: 2020-09-01

Close Date: 2025-11-30

Grant: Close

Development of a multi-omic clinical decision platform to guide personalized therapy

Open Date: 2020-02-06

Close Date: 2026-01-31

Grant: Close

Patient-Specific Mutation-Derived Tumor Neoantigens as Targets for Cancer Immunotherapy in Smoldering Multiple Myeloma

Open Date: 2018-01-01

Close Date: 2019-12-31

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Collaborators (24)

Mounzer Agha

Associate Professor

University of Pittsburgh

UNITED STATES

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Himanshu Joshi

Associate Professor

Icahn School of Medicine at Mount Sinai

UNITED STATES

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Carolina Schinke

University of Arkansas for Medical Sciences

UNITED STATES

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Zachary Avigan

Assistant Professor

Icahn School of Medicine at Mount Sinai

UNITED STATES

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Jill Corre

FRANCE

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Brian Walker

Professor

University of Miami

UNITED STATES

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Vu Ngo

Beckman Research Institute, City of Hope

UNITED STATES

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Heng-Huan Lee

Assistant Professor

The University of Texas MD Anderson Cancer Center

UNITED STATES

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Martin Kaiser

Professor of Haematology

The Institute of Cancer Research & The Royal Marsden NHS Foundation Trust

UNITED KINGDOM

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Noopur Raje

Harvard University

UNITED STATES

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Roberto C. Delgado Bolton

SPAIN

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Christian Salib

Assistant Professor, Assistant Director of Hematopathology Services

Icahn School of Medicine at Mount Sinai

UNITED STATES

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Patrick M. Brunner

Associate Professor

Icahn School of Medicine at Mount Sinai

UNITED STATES

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Robert Orlowski

Florence Maude Thomas Cancer Research Professor

The University of Texas MD Anderson Cancer Center

UNITED STATES

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Benjamin Barwick

Assistant Professor

Emory University

UNITED STATES

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Herve Avet-Loiseau

FRANCE

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Corynn Kasap

University of California, San Francisco

UNITED STATES

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Bruno David Lourenço Paiva

Clinica Universidad de Navarra

SPAIN

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Husnu Umit Kaniskan

Associate Professor

Icahn School of Medicine at Mount Sinai

UNITED STATES

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Norma C. Gutiérrez

SPAIN

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Marc S. Raab

University Hospital Heidelberg

GERMANY

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Violetta Leshchenko

Senior Scientist

Icahn School of Medicine at Mount Sinai

UNITED STATES

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Matthew Croken

Assistant Professor

Icahn School of Medicine at Mount Sinai

UNITED STATES

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Adam Cohen

Associate Professor, Clinician-Educator

University of Pennsylvania

UNITED STATES

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Samir Parekh

Research Interests

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Recent Grants

Articles (20)

Progressive multifocal leukoencephalopathy and BIZ virus-nephropathy with bispecific antibody therapy in multiple myeloma

Targeted Therapy of CAR+ T-Cell Lymphoma after Anti-BCMA CAR T-Cell Therapy

CEACAM1 as a mediator of B-cell receptor signaling in mantle cell lymphoma.

SOX11 Modulates BCR Signaling Through the PAX5/CD19 Axis for Therapeutic Targeting in BTK Resistant Mantle Cell Lymphoma

Long-Term (≥5-Year) Remission and Survival After Treatment With Ciltacabtagene Autoleucel in CARTITUDE-1 Patients With Relapsed/Refractory Multiple Myeloma

Targeting high-risk multiple myeloma genotypes with optimized anti-CD70 CAR T cells

International Myeloma Society/International Myeloma Working Group Consensus Recommendations on the Definition of High-Risk Multiple Myeloma

Clonal hematopoiesis and inflammation predict hematologic toxicity and secondary myeloid malignancies after BCMA-directed chimeric antigen receptor T cell therapy.

Comparison of MRI, [18F]FDG-PET/CT, and [18F]FDG-PET/MRI for Initial Staging of Multiple Myeloma

Infections and parameters of humoral immunity with talquetamab in relapsed/refractory multiple myeloma in MonumenTAL-1

Delayed neutrophil recovery following BCMA CAR-T therapy in Duffy-null myeloma does not impact severe infections or survival

Affinity-matured CD72-targeting nanobody CAR T cells enhance elimination of antigen-low B-cell malignancies

Anti-CD72 nanobody-based CAR-T affinity maturation leads to improved in vitro efficacy versus low antigen density lymphoma models, but limited benefit in vivo

At the cusp of a cure in Myeloma: Insights into pathogenesis, modeling and therapeutics

Extramedullary disease but not paraskeletal disease portends inferior outcomes after CAR T cell therapy in multiple myeloma

FaMMily Affairs: Dissecting inherited contributions to multiple myeloma risk

Guardians of the tumor microenvironment: the neutrophil saga

International Myeloma Society/International Myeloma Working Group Consensus Recommendations on the Definition of High-Risk Multiple Myeloma (Jun, 10.1200/JCO-24-01893, 2025)

MRD-negative duration following latest line of therapy predicts long-term PFS in real-world patients with multiple myeloma

PGV001, a Multi-Peptide Personalized Neoantigen Vaccine Platform: Phase I Study in Patients with Solid and Hematologic Malignancies in the Adjuvant Setting

Collaborators (24)

Mounzer Agha

Himanshu Joshi

Carolina Schinke

Zachary Avigan

Jill Corre

Brian Walker

Vu Ngo

Heng-Huan Lee

Martin Kaiser

Noopur Raje

Roberto C. Delgado Bolton

Christian Salib

Patrick M. Brunner

Robert Orlowski

Benjamin Barwick

Herve Avet-Loiseau

Corynn Kasap

Bruno David Lourenço Paiva

Husnu Umit Kaniskan

Norma C. Gutiérrez

Marc S. Raab

Violetta Leshchenko

Matthew Croken

Adam Cohen

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