Sarah C. Huen
United StatesResearch Interests
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Articles (4)
Year:
2025
Year:
2024
The mitochondrial enzyme hydroxymethylglutaryl-CoA synthase 2 (HMGCS2) catalyzes the rate-limiting step of ketogenesis. Although the liver constitutively expresses HMGCS2 and is considered the main ketogenic organ, HMGCS2 is induced in the kidney during fasting, leading to the proposal that the kidney contributes to fasting ketosis. We showed kidney HMGCS2 does not contribute to circulating ketones during fasting and cannot compensate for hepatic ketogenic insufficiency.
Year:
2022
Year:
2021
Collaborators (3)
Lauren Elizabeth Lee
University of Pennsylvania
Andrew Wang
Yale University
Benjamin D. Humphreys
Washington University in Saint Louis School of Medicine
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