Lauren Elizabeth Lee

University of Pennsylvania
Country flagUnited States

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Articles (2)

Year:

2024

The mitochondrial enzyme hydroxymethylglutaryl-CoA synthase 2 (HMGCS2) catalyzes the rate-limiting step of ketogenesis. Although the liver constitutively expresses HMGCS2 and is considered the main ketogenic organ, HMGCS2 is induced in the kidney during fasting, leading to the proposal that the kidney contributes to fasting ketosis. We showed kidney HMGCS2 does not contribute to circulating ketones during fasting and cannot compensate for hepatic ketogenic insufficiency.

Year:

2022

Collaborators (3)

Sarah C. Huen

University of Texas Southwestern Medical Center

UNITED STATES
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Tomohito Doke

Assistant Professor

Nagoya University Graduate School of Medicine

JAPAN
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Katalin Susztak

Professor

University of Pennsylvania

UNITED STATES
View details
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