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Sarah Costantino

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Phd, Group leader

University Hospital of Zurich

Switzerland

Research Interests

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Professors in Switzerland

Recent Grants

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Autophagy in obesity-induced pulmonary hypertension

Open Date: 2025-09-01

Close Date:

Grant: Close

Epigenetic remodeling of perivascular adipose tissue in HfpEF

Open Date: 2025-09-01

Close Date:

Grant: Close

Epigenetic remodeling of perivascular adipose tissue: focus on BET protein inhibitors

Open Date: 2025-01-01

Close Date:

Grant: Close

Potential effects of BET Inhibitor targeting paracrine Endothelial-Fibroblast Crosstalk in a Novel Experimental Model of Pulmonary Arterial Hypertension

Open Date: 2024-10-01

Close Date:

Grant: Close

Long non-coding RNA PANDA involvement in diabetic vascular dysfunction

Open Date: 2024-09-01

Close Date:

Articles (20)

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2026

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2025

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2025

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2024

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2024

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2023

Year:

2023

Collaborators (13)

Assam El-Osta

University of Melbourne

AUSTRALIA

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Alessandro Mengozzi

Assistant Professor

University of Pisa

ITALY

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Omer Dzemali

Director, Prof. Dr. Dr. h.c.

University of Zurich

SWITZERLAND

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Andreas J. Hülsmeier

University Hospital of Zurich

SWITZERLAND

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Stefano Ministrini

Researcher

University of Zurich

SWITZERLAND

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Mattia Albiero

Assistant Professor

University of Padova

ITALY

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Claudia Agabiti Rosei

Docenti di ruolo di IIa fascia

University of Brescia

ITALY

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David Niederseer

SWITZERLAND

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Livia de Lucca Camargo

Research Institute of the McGill University Health Centre

CANADA

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Attila Kiss

Assistant Professor

Medical University of Vienna

AUSTRIA

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Frank Ruschitzka

Professor and Head of Cardiology

SWITZERLAND

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Edna Grünblatt

SWITZERLAND

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Simon Tual-Chalot

Newcastle University

UNITED KINGDOM

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Sarah Costantino

Research Interests

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Recent Grants

Articles (20)

Histamine N-methyltransferase in heart failure: from metabolic signalling to chromatin remodelling

Tenascin-C drives cardiovascular dysfunction in a mouse model of diabetic cardiomyopathy

Targeting SETD7 Rescues Diabetes-Induced Impairment of Angiogenic Response by Transcriptional Repression of Semaphorin-3G

Chromatin Rewiring by SETD2 Drives Lipotoxic Injury in Cardiometabolic HFpEF

Single nuclei RNA-sequencing unveils alveolar macrophages as drivers of endothelial damage in obese HFpEF-related pulmonary hypertension.

Cardiometabolic disease management: influences from epigenetics

Air pollution modulates brown adipose tissue function through epigenetic regulation by HDAC9 and KDM2B.

Targeting the Epigenetic Remodeler GCN5 Prevents Vascular Oxidative Stress and Endothelial Dysfunction in Obesity: Insights in Patients with Cardiometabolic Disease.

miR-451 Is a Driver of Lipotoxic Injury in Patients with Diabetic Cardiomyopathy.

Cardiometabolic heart failure with preserved ejection fraction: from molecular signatures to personalized treatment.

Messenger RNA (mRNA) based therapeutics in transforming cardiovascular care: Progress, regulatory challenges and future perspectives.

Regulation of cardiac hypertrophy by RNA readers.

The H2S-donor Erucin modulates SIRT1 and rescues obesity-induced vascular dysfunction in human vessels.

Long-lasting metabolic impairment in the failing heart: epigenetic memories at play.

Endothelial dysfunction in patients with type 2 diabetes: the truth is in the blood.

NAD<sup>+</sup> boosting increases atherosclerotic plaques and inflammation in Apoe knockout mice.

Mechanisms of Vascular Inflammation and Potential Therapeutic Targets: A Position Paper From the ESH Working Group on Small Arteries

Persistent epigenetic signals propel a senescence-associated secretory phenotype and trained innate immunity in CD34+ hematopoietic stem cells from diabetic patients

Long non-coding RNAs H19 and NKILA are associated with the risk of death and lacunar stroke in the elderly population.

Treatment with recombinant Sirt1 rewires the cardiac lipidome and rescues diabetes-related metabolic cardiomyopathy

Collaborators (13)

Assam El-Osta

Alessandro Mengozzi

Omer Dzemali

Andreas J. Hülsmeier

Stefano Ministrini

Mattia Albiero

Claudia Agabiti Rosei

David Niederseer

Livia de Lucca Camargo

Attila Kiss

Frank Ruschitzka

Edna Grünblatt

Simon Tual-Chalot

Make your next move.

Sarah Costantino

Research Interests

Explore related searches

Recent Grants

Articles (20)

Histamine N-methyltransferase in heart failure: from metabolic signalling to chromatin remodelling

Tenascin-C drives cardiovascular dysfunction in a mouse model of diabetic cardiomyopathy

Targeting SETD7 Rescues Diabetes-Induced Impairment of Angiogenic Response by Transcriptional Repression of Semaphorin-3G

Chromatin Rewiring by SETD2 Drives Lipotoxic Injury in Cardiometabolic HFpEF

Single nuclei RNA-sequencing unveils alveolar macrophages as drivers of endothelial damage in obese HFpEF-related pulmonary hypertension.

Cardiometabolic disease management: influences from epigenetics

Air pollution modulates brown adipose tissue function through epigenetic regulation by HDAC9 and KDM2B.

Targeting the Epigenetic Remodeler GCN5 Prevents Vascular Oxidative Stress and Endothelial Dysfunction in Obesity: Insights in Patients with Cardiometabolic Disease.

miR-451 Is a Driver of Lipotoxic Injury in Patients with Diabetic Cardiomyopathy.

Cardiometabolic heart failure with preserved ejection fraction: from molecular signatures to personalized treatment.

Messenger RNA (mRNA) based therapeutics in transforming cardiovascular care: Progress, regulatory challenges and future perspectives.

Regulation of cardiac hypertrophy by RNA readers.

The H2S-donor Erucin modulates SIRT1 and rescues obesity-induced vascular dysfunction in human vessels.

Long-lasting metabolic impairment in the failing heart: epigenetic memories at play.

Endothelial dysfunction in patients with type 2 diabetes: the truth is in the blood.

NAD&lt;sup&gt;+&lt;/sup&gt; boosting increases atherosclerotic plaques and inflammation in Apoe knockout mice.

Mechanisms of Vascular Inflammation and Potential Therapeutic Targets: A Position Paper From the ESH Working Group on Small Arteries

Persistent epigenetic signals propel a senescence-associated secretory phenotype and trained innate immunity in CD34+ hematopoietic stem cells from diabetic patients

Long non-coding RNAs H19 and NKILA are associated with the risk of death and lacunar stroke in the elderly population.

Treatment with recombinant Sirt1 rewires the cardiac lipidome and rescues diabetes-related metabolic cardiomyopathy

Collaborators (13)

Assam El-Osta

Alessandro Mengozzi

Omer Dzemali

Andreas J. Hülsmeier

Stefano Ministrini

Mattia Albiero

Claudia Agabiti Rosei

David Niederseer

Livia de Lucca Camargo

Attila Kiss

Frank Ruschitzka

Edna Grünblatt

Simon Tual-Chalot

Make your next move.

NAD<sup>+</sup> boosting increases atherosclerotic plaques and inflammation in Apoe knockout mice.