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Sarel Fleishman

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Professor

Weizmann Institute of Science

Israel

Research Interests

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Professors in Biochemistry

Recent Grants

Grant: Open

ARC Centre of Excellence in Synthetic Biology

Open Date: 2020-01-01

Close Date: 2026-12-31

Grant: Close

Automated computational design of site-targeted repertoires of camelid antibodies

Open Date: 2019-01-01

Close Date: 2023-12-31

Grant: Close

Computational design of new and improved enzymes guided by evolutionary principles

Open Date: 2019-01-01

Close Date: 2023-12-31

Grant: Close

How did proteins emerge and continue to evolve?

Open Date: 2018-06-25

Close Date: 2023-06-25

Grant: Close

Testing the restricted germline hypothesis for broadly neutralizing antibodies directed against the CD4bs of HIV-1 Env

Open Date: 2015-01-01

Close Date: 2017-12-31

Articles (20)

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2023

Collaborators (8)

Roni Oren

Head of Patient Derived Xenograft (PDX) Service and Human Tissue Samples Bank

Weizmann Institute of Science

ISRAEL

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Inbal Eti Biton

Head of MRI/CT unit

Weizmann Institute of Science

ISRAEL

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Melissa Call

Laboratory Head

Walter and Eliza Hall Institute of Medical Research

AUSTRALIA

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Rhea Longley

Laboratory Head

Walter and Eliza Hall Institute of Medical Research

AUSTRALIA

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Birte Höcker

Professor

University of Bayreuth

GERMANY

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Jordi Soler

University of Oxford

UNITED KINGDOM

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Shina Caroline Lynn Kamerlin

Professor and Georgia Research Alliance Eminent Scholar

Georgia Institute of Technology

UNITED STATES

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Matthew Call

Associate Professor

University of Melbourne

AUSTRALIA

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Sarel Fleishman

Research Interests

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Recent Grants

Articles (20)

The transmembrane domain structure of TNFR1 suppresses ligand-independent autoactivation but is not required for TNF-induced signaling

Computational design of optimized and preferentially paired human TCR constant regions for improved T cell function

De novo enzyme design: Controlling structure to design function

Complete Biosynthesis of Psychedelic Tryptamines from Three Kingdoms in Plants

Optimizing Stability in Dynamic Small-Molecule Binding Proteins

Computationally Designed Peroxygenases That Exhibit Diverse and Selective Terpene Oxyfunctionalization

Stabilized designs of the malaria adhesin protein PvRBP2b for use as a potential diagnostic for Plasmodium vivax.

Complete computational design of high-efficiency Kemp elimination enzymes

Evolutionary paths that link orthogonal pairs of binding proteins.

htFuncLib: Designing Libraries of Active-site Multipoint Mutants for Protein Optimization.

Efficacy of an AAV vector encoding a thermostable form of glucocerebrosidase in alleviating symptoms in a Gaucher disease mouse model

GGAssembler: Precise and economical design and synthesis of combinatorial mutation libraries

Addressing epistasis in the design of protein function

Opportunities and challenges in design and optimization of protein function

Preclinical development of a stabilized RH5 virus-like particle vaccine that induces improved antimalarial antibodies.

One‐shot design elevates functional expression levels of a voltage‐gated potassium channel

Functionally Diverse Peroxygenases by AlphaFold2, Design, and Signal Peptide Shuffling

Computational optimization of antibody humanness and stability by systematic energy-based ranking.

The C-terminal tail of CSNAP attenuates the CSN complex.

Stable Mammalian Serum Albumins Designed for Bacterial Expression.

Collaborators (8)

Roni Oren

Inbal Eti Biton

Melissa Call

Rhea Longley

Birte Höcker

Jordi Soler

Shina Caroline Lynn Kamerlin

Matthew Call

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