Shan Yan

Professor

University of North Carolina at Charlotte

United States

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About

Shan Yan is a Professor at the University of North Carolina at Charlotte. His research primarily focuses on genome integrity mechanisms, including the DNA damage response and the regulation of proteins involved in this process. Recent publications highlight his work on the roles of APE1 and APE2 in DNA repair and the implications for cancer therapy. He contributes to advancing understanding of the interplay between DNA damage signaling and cellular responses.

Articles (15)

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2024

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2024

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2022

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2021

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2021

Collaborators (4)

Haichao Zhao

University of North Carolina at Charlotte

UNITED STATES

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Zhongsheng You

Associate Professor

Washington University in Saint Louis School of Medicine

UNITED STATES

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Robert Sobol

Professor & Associate Director for Basic Research

Brown University

UNITED STATES

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shobhan gaddameedhi

North Carolina State University

UNITED STATES

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Shan Yan

Research Interests

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Articles (15)

Inspiring basic and applied research in genome integrity mechanisms: Dedication to Samuel H. Wilson

Distinct regulation of ATM signaling by DNA single-strand breaks and APE1

Ubiquitin-mediated regulation of APE2 protein abundance

cGAS mediates the inflammatory responses of human microglial cells to genotoxic DNA damage

APE1 is a master regulator of the ATR-/ATM-mediated DNA damage response

Maintaining chromosome and genome stability by the RPA–RNF20–SNF2H cascade

APE1 recruits ATRIP to ssDNA in an RPA-dependent and -independent manner to promote the ATR DNA damage response

Molecular mechanisms of nucleolar DNA damage checkpoint response

APE2: catalytic function and synthetic lethality draw attention as a cancer therapy target

APE1 assembles biomolecular condensates to promote the ATR–Chk1 DNA damage response in nucleolus

Editorial: Mechanistic studies of genome integrity, environmental health, and cancer etiology

Multiple myeloma etiology and treatment

Advanced Nanoengineering Approach for Target‐Specific, Spatiotemporal, and Ratiometric Delivery of Gemcitabine–Cisplatin Combination for Improved Therapeutic Outcome in Pancreatic Cancer

APE2 Is a General Regulator of the ATR-Chk1 DNA Damage Response Pathway to Maintain Genome Integrity in Pancreatic Cancer Cells

Mechanisms of Ataxia Telangiectasia Mutated (ATM) Control in the DNA Damage Response to Oxidative Stress, Epigenetic Regulation, and Persistent Innate Immune Suppression Following Sepsis

Collaborators (4)

Haichao Zhao

Zhongsheng You

Robert Sobol

shobhan gaddameedhi

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