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Shiang Yong Lim

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Principal Investigator, Group Leader, Cardiac Regeneration Laboratory

St Vincent's Institute of Medical Research

Australia

Research Interests

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Recent Grants

Grant: Open

Defining and targeting cardiac lipid dysregulation in Friedreich ataxia using human iPSC-derived cardiac models

Open Date: 2026-01-01

Close Date: 2028-01-01

Grant: Open

Phase 1b Study of Sustained Release Stem Cell Secretome: Safety and Exploratory efficacy in Acute Myocardial Infarction (SECRETOME-AMI).

Open Date: 2026-01-01

Close Date: 2029-01-01

Grant: Close

Transforming diabetes care: cardiorenal interactions in a pre-clinical model for therapeutic discovery

Open Date: 2025-01-01

Close Date: 2025-01-01

Grant: Close

Targeting fibrosis in women with type 2 diabetes: sex-specific optimal heart failure management

Open Date: 2025-01-01

Close Date: 2026-01-01

Grant: Close

Evaluating the cardioprotective effect of omaveloxolone on Friedreich ataxia heart disease.

Open Date: 2024-01-01

Close Date: 2025-01-01

Articles (20)

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Head of Centre and Research Group Leader

Baker Heart and Diabetes Institute

AUSTRALIA

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ApplyKite TwinLearns as you apply

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Shiang Yong Lim

Research Interests

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Recent Grants

Articles (20)

The Drp1 inhibitor DRP1i2 confers cardioprotection against doxorubicin-induced cardiotoxicity

An Integrated Cardiac Microtissue Proteome Map Extends Therapeutic Remodeling by Nanovesicles

Modular cardiac microtissues for interrogating cell-type contributions

Cardiac SGLT2 Expression and Cell-Type-Specific Responses to Empagliflozin in iPSC-Derived Models of Diabetic Cardiomyopathy

Frataxin deficiency drives cardiac dysfunction and transcriptional dysregulation in Friedreich ataxia iPSC model

Hypoxia Modulates Nanovesicle Phenotype and Angiogenic Function From Human Pluripotent Stem Cells

Long-read sequencing-based atlas of tissue-specific expression of DNM1L transcript variants

Omaveloxolone for the Treatment of Friedreich Ataxia: Efficacy, Safety, and Future Perspectives

Device encapsulated MSCs for adaptive secretome therapy to effectively target ischaemic heart injury

Methods for Assessing Scaffold Vascularization with Human Endothelial Cells.

Emerging therapies for Friedreich Ataxia and the prospect of future combination treatments

Precision Medicine

Real-time electro-mechanical profiling of dynamically beating human cardiac organoids by coupling resistive skins with microelectrode arrays

Autism Spectrum Disorder Induced Pluripotent Stem Cells Display Dysregulated Calcium Signaling During Neural Differentiation

MitoQ Protects Against Oxidative Stress-Induced Mitochondrial Dysregulation in Human Cardiomyocytes

Modelling diabetes-associated metabolic stress in human multicellular cardiac microtissues

Acute Inhibition of Drp1 Mitigates Adverse Cardiac Remodelling following Chronic Reperfused Myocardial Infarction

NOS3 regulates angiogenic potential of human induced pluripotent stem cell-derived endothelial cells

Cardiac-targeted delivery of a novel Drp1 inhibitor for acute cardioprotection

Novel mitochondria-targeted therapy AP39 limits mitochondrial dysregulation and diastolic dysfunction in 2D & 3D human models of diabetic cardiomyopathy

Collaborators (9)

Simon Bond

Jarmon Gerald Lees

Guei-Sheung Liu

Yow Keat Tham

Saba Naghipour

Raymond Ching-Bong Wong

Andrew Kompa

Jafar S. Jabbari

Daniel G Donner

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