Shigenobu Matsumura

Osaka University

Japan

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Articles (8)

Year:

2024

Year:

2022

Year:

2022

We report that G s signaling in melanocortin 4 receptor (MC4R)-expressing cells regulates energy expenditure, appetite, and locomotor activity. These findings shed light on the mechanism underlying the regulation of energy metabolism and locomotor activity by MC4R/cAMP signaling.

Year:

2022

Year:

2022

Year:

2021

Year:

2021

Year:

2021

Collaborators (8)

tsutomu sasaki

Osaka University

JAPAN

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Tohru Hira

Hokkaido University

JAPAN

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Hiroaki Kanouchi

Professor

Osaka University

JAPAN

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Takahiro Horie

准教授 / Associate Professor

Kyoto University

JAPAN

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Tsuyoshi Goto

准教授 / Associate Professor

Kyoto University

JAPAN

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Naoki Harada

Osaka University

JAPAN

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Takumi Yokokawa

Assistant Professor

Kyoto University

JAPAN

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Kazuo Inoue

Kyoto University

JAPAN

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Shigenobu Matsumura

Research Interests

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Articles (8)

Low cellular pyridoxal 5ʹ-phosphate levels decrease neurotransmitter and glutathione concentrations and increase susceptibility to hydrogen peroxide toxicity in SH-SY5Y cells

CRTC1 deficiency, specifically in melanocortin-4 receptor-expressing cells, induces hyperphagia, obesity, and insulin resistance

Identification of G protein-coupled receptor 55 (GPR55) as a target of curcumin

Stimulation of G<sub>s</sub> signaling in MC4R cells by DREADD increases energy expenditure, suppresses food intake, and increases locomotor activity in mice

Disruption of CRTC1 and CRTC2 in Sim1 cells strongly increases high-fat diet intake in female mice but has a modest impact on male mice

Loss of CREB Coactivator CRTC1 in SF1 Cells Leads to Hyperphagia and Obesity by High-fat Diet But Not Normal Chow Diet

Activation of the adipocyte CREB/CRTC pathway in obesity

microRNA-33 maintains adaptive thermogenesis via enhanced sympathetic nerve activity

Collaborators (8)

tsutomu sasaki

Tohru Hira

Hiroaki Kanouchi

Takahiro Horie

Tsuyoshi Goto

Naoki Harada

Takumi Yokokawa

Kazuo Inoue

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