Shinobu Tsuzuki

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Aichi Medical University

Japan

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Shinobu Tsuzuki is a Professor at Aichi Medical University in Japan. His research primarily focuses on the molecular mechanisms underlying various leukemias, including T-cell and B-cell acute lymphoblastic leukemias, as well as multiple myeloma. Recent publications highlight novel therapeutic targets and genetic characteristics associated with these malignancies.

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Elucidation of multi-step mechanisms of leukemogenesis from the perspective of fusion-genes

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Articles (11)

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2024

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2022

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2021

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2020

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2020

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2020

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2020

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2020

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2020

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Aichi Medical University

JAPAN

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Shinobu Tsuzuki

Research Interests

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Recent Grants

Articles (11)

Suppression of super-enhancer-driven TAL1 expression by KLF4 in T-cell acute lymphoblastic leukemia

Two novel high-risk adult B-cell acute lymphoblastic leukemia subtypes with high expression of CDX2 and IDH1/2 mutations

CD52 is a novel target for the treatment of FLT3-ITD-mutated myeloid leukemia

Biallelic loss of FAM46C triggers tumor growth with concomitant activation of Akt signaling in multiple myeloma cells

Discovery of novel molecular characteristics and cellular biological properties in ameloblastoma

Tandem Paired Nicking Promotes Precise Genome Editing with Scarce Interference by p53

Identification of CD24 as a potential diagnostic and therapeutic target for malignant pleural mesothelioma.

Novel Interleukin-6 Inducible Gene PDZ-Binding Kinase Promotes Tumor Growth of Multiple Myeloma Cells.

Targeting MEF2D-fusion Oncogenic Transcriptional Circuitries in B-cell Precursor Acute Lymphoblastic Leukemia.

High prevalence of MEF2D fusion in human B-cell precursor acute lymphoblastic leukemia cell lines.

Staurosporine and venetoclax induce the caspase-dependent proteolysis of MEF2D-fusion proteins and apoptosis in MEF2D-fusion (+) ALL cells

Collaborators (6)

Sivasundaram Karnan

Takuji Ito

Akinobu Ota

Kaori Uchino

Hiroyuki Konishi

Toshinori Hyodo

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