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Silvia Bolognin

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Assistant Professor/ Principal Investigator

Netherlands

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About

Silvia Bolognin is an Assistant Professor and Principal Investigator at UM-MERLN in the Netherlands. Her research focuses on Parkinson's disease, particularly the role of transcription factors, astrocyte senescence, and neuron differentiation. Recent publications highlight advancements in targeting cellular pathways and exploring the interactions between the nervous system and other biological systems.

Recent Grants

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The role of NR2F1 in Parkinson's Disease

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Development of a midbrain-on-a-chip model for Parkinson's disease

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The role of the Rho-GTPase proteins in the aetiology of Alzheimer's disease

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Autophagy modulation to decrease astrocyte senescence in LRRK2-G2019S models

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Advanced machine learning tools to study neuronal Ca2+ fluxes in human organoids

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Articles (14)

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2025

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2024

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2023

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2022

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2021

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2021

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2021

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2020

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2020

Collaborators (6)

Jens C. Schwamborn

LUXEMBOURG

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Katarzyna Wolynska (Maiden: Wicher)

PhD, Assistant Professor

Poznan University of Medical Sciences

POLAND

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Lasse Sinkkonen

Research Scientist

University of Luxembourg

LUXEMBOURG

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Eugenio Fava

Head

Human Technopole

ITALY

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Maria Teresa Valenti

University of Verona

ITALY

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Luca Dalle Carbonare

University of Verona

ITALY

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Silvia Bolognin

Research Interests

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About

Recent Grants

Articles (14)

Transcription factor NR2F1 is involved in Parkinson's disease

Alpha-synuclein pathology is associated with astrocyte senescence in a midbrain organoid model of familial Parkinson's disease

Targeting Human Endothelial Cells with Glutathione and Alanine Increases the Crossing of a Polypeptide Nanocarrier through a Blood-Brain Barrier Model and Entry to Human Brain Organoids.

Multiomics analysis identifies novel facilitators of human dopaminergic neuron differentiation

Impaired neuron differentiation in GBA-associated Parkinson’s disease is linked to cell cycle defects in organoids

Bone Tissue and the Nervous System: What Do They Have in Common?

Integrated, automated maintenance, expansion and differentiation of 2D and 3D patient-derived cellular models for high throughput drug screening

A Triple Combination of Targeting Ligands Increases the Penetration of Nanoparticles across a Blood-Brain Barrier Culture Model

The Parkinson’s-disease-associated mutation LRRK2-G2019S alters dopaminergic differentiation dynamics via NR2F1

Transition metal dichalcogenides to optimize the performance of peptide-imprinted conductive polymers as electrochemical sensors

Impaired dopamine D3 and nicotinic acetylcholine receptor membrane localization in iPSCs-derived dopaminergic neurons from two Parkinson’s disease patients carrying the LRRK2 G2019S mutation

Monitoring the neurotransmitter release of human midbrain organoids using a redox cycling microsensor as a novel tool for personalized Parkinson's disease modelling and drug screening.

A patient-based model of RNA mis-splicing uncovers treatment targets in Parkinson’s disease

Reduced astrocytic reactivity in human brains and midbrain organoids with PRKN mutations.

Collaborators (6)

Jens C. Schwamborn

Katarzyna Wolynska (Maiden: Wicher)

Lasse Sinkkonen

Eugenio Fava

Maria Teresa Valenti

Luca Dalle Carbonare

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