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Silvia Pomella

Has grant

RTT

University of Rome Tor Vergata

Italy

Research Interests

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Professors in Italy Professors in Cell Biology Cell Biology professors in Italy

Recent Grants

Grant: Open

Targeting resistance to BET inhibitors to dissect and overcome fusion-addicted oncogenic enhancer adaptation mechanisms in pediatric PAX3-FOXO1 rhabdomyosarcoma

Open Date: 2023-04-01

Close Date: 2026-12-01

Grant: Close

MEK targeting to boost enhancer-dependencies and counteract drug resistance in Rhabdomyosarcoma

Open Date: 2022-01-01

Close Date: 2022-12-01

Grant: Close

MYCN peptide-dependent targeting in PAX3-FOXO1 rhabdomyosarcoma to impair tumorigenic cell properties and overcome resistance to BRD4 inhibition

Open Date: 2020-04-01

Close Date: 2021-03-01

Grant: Close

BET bromodomain proteins degraders as potential agents for targeted therapy in high-risk Rhabdomyosarcoma

Open Date: 2019-04-01

Close Date: 2020-03-01

Grant: Close

Identification of mechanisms of resistance to BRD4 inhibition in pediatric rhabdomyosarcoma

Open Date: 2018-01-01

Close Date: 2018-12-01

Articles (20)

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Collaborators (19)

Roberto Bei

ITALY

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Beat W. Schäfer

University Children's Hospital

SWITZERLAND

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Clemens Zwergel

Tenure-track Assistant Professor RTT

Sapienza University of Rome

ITALY

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Benjamin Stanton

Assistant Professor

UNITED STATES

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Eugenia Quiros-Roldan

Profesor

University of Brescia

ITALY

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Zoe Walters

University of Southampton

UNITED KINGDOM

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Alessandro Rosa

Full Professor

Sapienza University of Rome

ITALY

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Serena Carra

Associate Professor of Molecular Biology

University of Modena and Reggio Emilia

ITALY

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Mark Hatley

Associate Member

St. Jude Children's Research Hospital

UNITED STATES

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Giovanni Corsetti

Professor

University of Brescia

ITALY

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Alessandro FANZANI

Associate Professor in Biochemistry

University of Brescia

ITALY

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Rossella Rota

Group Leader

Ospedale Pediatrico Bambino Gesù

ITALY

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Jack Shern

Head, Tumor Evolution and Genomics Section

National Institutes of Health

UNITED STATES

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Biagio De Angelis

Dirigente Farmacista

Ospedale Pediatrico Bambino Gesù

ITALY

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Yong Yean Kim

Assistant Professor

Stanford University

UNITED STATES

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Ernesto Guccione

Professor

Icahn School of Medicine at Mount Sinai

UNITED STATES

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Loredana Cifaldi

Associate Professor of General Pathology

University of Rome Tor Vergata

ITALY

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Katie Hebron

Assistant Professor

Purdue University

UNITED STATES

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Simone Hettmer

University Medical Center Freiburg

GERMANY

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Silvia Pomella

Research Interests

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Recent Grants

Articles (20)

Catalase Defines Radiotherapy Resistance and a Therapeutic Vulnerability in Rhabdomyosarcoma

Biological Advances and Current Challenges for Pediatric Rhabdomyosarcoma

Lactate-mediated NK cell dysfunction as a prognostic marker and therapeutic target in breast cancer

From bench to bedside: combining HDAC inhibitors with standard therapies in rhabdomyosarcoma treatment

Fibronectin Is a Likely Therapeutic Target Shared by Oral and Breast Carcinomas

Inhibition of bromodomain and extra-terminal motif (BET) proteins in pediatric sarcoma: A systematic review of in vitro and in vivo studies

The HIV Protease Inhibitor Ritonavir Reverts the Mesenchymal Phenotype Induced by Inflammatory Cytokines in Normal and Tumor Oral Keratinocytes to an Epithelial One, Increasing the Radiosensitivity of Tumor Oral Keratinocytes

Neddylation inhibition induces DNA double-strand breaks, hampering tumor growth in vivo, and promotes radiosensitivity in PAX3–FOXO1 rhabdomyosarcoma

Ritonavir and DNA Damage: A New Perspective on an Old Drug

HDAC3 genetic and pharmacologic inhibition radiosensitizes fusion positive rhabdomyosarcoma by promoting DNA double-strand breaks

Biomarkers Identification in the Microenvironment of Oral Squamous Cell Carcinoma: A Systematic Review of Proteomic Studies

KDM3B inhibitors disrupt the oncogenic activity of PAX3-FOXO1 in fusion-positive rhabdomyosarcoma

Tumor-derived G-CSF induces an immunosuppressive microenvironment in an osteosarcoma model, reducing response to CAR.GD2 T-cells

Effects of Angiogenic Factors on the Epithelial-to-Mesenchymal Transition and Their Impact on the Onset and Progression of Oral Squamous Cell Carcinoma: An Overview

Antitumour effects of SFX-01 molecule in combination with ionizing radiation in preclinical and in vivo models of rhabdomyosarcoma

Epigenetic determinants of fusion-driven sarcomas: paradigms and challenges

About a Possible Impact of Endodontic Infections by Fusobacterium nucleatum or Porphyromonas gingivalis on Oral Carcinogenesis: A Literature Overview

Heat Shock Proteins: Important Helpers for the Development, Maintenance and Regeneration of Skeletal Muscles

Genomic and Epigenetic Changes Drive Aberrant Skeletal Muscle Differentiation in Rhabdomyosarcoma

MYOD-SKP2 axis boosts tumorigenesis in fusion negative rhabdomyosarcoma by preventing differentiation through p57<sup>Kip2</sup> targeting

Collaborators (19)

Roberto Bei

Beat W. Schäfer

Clemens Zwergel

Benjamin Stanton

Eugenia Quiros-Roldan

Zoe Walters

Alessandro Rosa

Serena Carra

Mark Hatley

Giovanni Corsetti

Alessandro FANZANI

Rossella Rota

Jack Shern

Biagio De Angelis

Yong Yean Kim

Ernesto Guccione

Loredana Cifaldi

Katie Hebron

Simone Hettmer

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