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Simon Boulton

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Senior Group Leader

The Francis Crick Institute

United Kingdom

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Grant: Open

SLFN11 in replication stress tolerance in cancer and therapy resistance

Open Date: 2026-10-01

Close Date: 2032-09-30

Articles (11)

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2026

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2023

Collaborators (10)

Gonzalo Rodriguez-Berriguete

University of Oxford

UNITED KINGDOM

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Gavin Kelly

The Francis Crick Institute

UNITED KINGDOM

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Simon Reed

Professor

Cardiff University School of Medicine

UNITED KINGDOM

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Femke de Vrij

Associate professor

Erasmus University Rotterdam

NETHERLANDS

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Stephen West

Senior Group Leader

The Francis Crick Institute

UNITED KINGDOM

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Steven Kushner

Professor

Columbia University

UNITED STATES

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Juliette Kamp

Erasmus University Rotterdam

NETHERLANDS

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Daniel Ebner

University of Oxford

UNITED KINGDOM

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Graeme Hewitt

CRUK RadNet Group Leader

King’s College London

UNITED KINGDOM

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Nausica Arnoult

Assistant Professor

University of Colorado Boulder

UNITED STATES

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Simon Boulton

Research Interests

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Recent Grants

Articles (11)

RPA exhaustion activates SLFN11 to eliminate cells with heightened replication stress

Cryo-EM visualization of RAD51 filament assembly and end-capping by XRCC3-RAD51C-RAD51D-XRCC2

Extraordinary collateral mutagenesis induced by CX-5461

Small-Molecule Polθ Inhibitors Provide Safe and Effective Tumor Radiosensitization in Preclinical Models

Modulating mutational outcomes and improving precise gene editing at CRISPR-Cas9-induced breaks by chemical inhibition of end-joining pathways

Integrated transcriptome landscape of ALS identifies genome instability linked to TDP-43 pathology.

Negative DNA supercoiling induces genome-wide Cas9 off-target activity.

The APE2 nuclease is essential for DNA double-strand break repair by microhomology-mediated end joining.

Structure and function of the RAD51B–RAD51C–RAD51D–XRCC2 tumour suppressor

Erratum: Errtum: Discovery, Characterization, and Structure-Based Optimization of Small-Molecule In Vitro and In Vivo Probes for Human DNA Polymerase Theta (Journal of Medicinal Chemistry (2022) 65: 20 (13879−13891) DOI: 10.1021/acs.jmedchem.2c01142)

Visualization of direct and diffusion-assisted RAD51 nucleation by full-length human BRCA2 protein

Collaborators (10)

Gonzalo Rodriguez-Berriguete

Gavin Kelly

Simon Reed

Femke de Vrij

Stephen West

Steven Kushner

Juliette Kamp

Daniel Ebner

Graeme Hewitt

Nausica Arnoult

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