Simon Reinke

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Core Unit "Cell and Tissue Harvesting"; Scientific & Technical Head

Charité - Universitätsmedizin Berlin

Germany

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About

Simon Reinke is the Scientific & Technical Head at Charité Universitätsmedizin Berlin, Germany. His research primarily focuses on the immunological aspects of bone healing and fracture repair, as evidenced by his recent work on CD8+ terminal differentiated effector memory cells and their prognostic implications in fracture healing. He is also involved in innovative therapeutic approaches for enhancing bone repair, including local iloprost therapy, and exploring the immune landscape in relation to orthopedic conditions.

Recent Grants

Grant: Close

Central Service Project C01 – Cell and Tissue Harvesting: Supply of functionally and immunologically characterised human samples for the CRC research projects

Open Date: 2021-01-01

Close Date: 2025-02-01

Grant: Close

Placenta-expanded adherent stromal cells (PLX-PAD) as an innovative therapy for improving recovery and survival following hip fracture arthroplasty – HIPGEN, a multicenter phase III trial

Open Date: 2018-01-01

Close Date: 2022-01-01

Grant: Close

Prospective validation study of CD8+TEMRA cells as a prognostic biomarker of healing outcome after fracture (BioBone).

Open Date: 2016-02-01

Close Date: 2023-12-01

Grant: Close

Terminally Differentiated CD8+ T Cells Negatively Affect Bone Regeneration in Humans

Open Date: 2013-10-01

Close Date: 2014-10-01

Articles (13)

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2025

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2022

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2022

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2022

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2020

Collaborators (17)

Tazio Maleitzke

Charité - Universitätsmedizin Berlin

GERMANY

Simon Reinke

Research Interests

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About

Recent Grants

Articles (13)

ILOBONE: A phase I/IIa randomized controlled trial to assess the safety and feasibility of local iloprost therapy for enhancing proximal humerus fracture healing- a pilot study design.

BioBone - A prospective, blinded, multicenter validation study of the CD8 + terminal differentiated effector memory cells (CD8 + TEMRA cells) as prognostic biomarker for disturbed fracture healing - study design.

Surface CD69-Negative CD4 and CD8 Bone Marrow-Resident Human Memory T Cells.

Long-term in vitro maintenance of plasma cells in a hydrogel-enclosed human bone marrow microphysiological 3D model system.

Prognostic implications of a CD8+TEMRA to CD4+Treg imbalance in mandibular fracture healing: a prospective analysis of immune profiles.

Chondrocyte Isolation from Loose Bodies—An Option for Reducing Donor Site Morbidity for Autologous Chondrocyte Implantation

Individual immune cell and cytokine profiles determine platelet-rich plasma composition.

Lower-limb internal loading and potential consequences for fracture healing

SARS-CoV-2 specific plasma cells acquire long-lived phenotypes in human bone marrow.

Resident memory CD4 <sup>+</sup> T lymphocytes mobilize from bone marrow to contribute to a systemic secondary immune reaction

A ubiquitous bone marrow reservoir of preexisting SARS-CoV-2-reactive memory CD4+ T lymphocytes in unexposed individuals.

HIPGEN: a randomized, multicentre phase III study using intramuscular PLacenta-eXpanded stromal cells therapy for recovery following hip fracture arthroplasty : a study design.

Metal‐Specific Biomaterial Accumulation in Human Peri‐Implant Bone and Bone Marrow

Collaborators (17)

Tazio Maleitzke

Jan Oliver Voss

Dirk Strunk

Dominik Adl Amini

Dimitrios Laurin Wagner

Anastasia Rakow

Sascha Tafelski

Lukas Mödl

Stephan Oehme

Philipp Damm

Matthias Pumberger

Jonas Kath

Chiara Romagnani

Stefan Frischbutter

Sarah Hochmann

Tobias Winkler

Hans-Dieter Volk

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