Simon Sedej

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Associate Professor

Medical University of Graz

Austria

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About

Dr. Simon Sedej is an Associate Professor at the Medical University of Graz, Austria. His research focuses on cardiac health, specifically in the areas of heart failure, autophagy, and the metabolic implications of obesity. Recent publications highlight his work on NAD+ repletion and its effects on cardioprotective mechanisms, as well as therapeutic strategies for ameliorating obesity-related heart failure.

Recent Grants

Grant: Close

High-resolution ultrasound for pre-clinical and translational cardiovascular research

Open Date: 2018-01-01

Close Date: 2020-01-01

Grant: Close

Metabolic Therapy for Managing Diastolic Heart Failure

Open Date: 2017-05-01

Close Date: 2020-10-01

Grant: Close

Metabolic Therapy for Managing Diastolic Heart Failure

Open Date: 2017-05-01

Close Date: 2020-10-01

Grant: Close

Cardioprotective mechanisms in aging

Open Date: 2015-02-01

Close Date: 2018-01-01

Grant: Close

Cardioprotective mechanisms in aging

Open Date: 2015-02-01

Close Date: 2018-01-01

Articles (20)

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2022

Collaborators (19)

Senka Ljubojevic-Holzer

Assistant Professor (Tenure track)

Medical University of Graz

AUSTRIA

Simon Sedej

Research Interests

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About

Recent Grants

Articles (20)

Roadmap for alleviating the manifestations of ageing in the cardiovascular system.

Mechano-energetic uncoupling in heart failure.

NAD&lt;sup&gt;+&lt;/sup&gt; repletion restores cardioprotective autophagy and mitophagy in obesity-associated heart failure by suppressing excessive trophic signaling.

Autophagy is required for the therapeutic effects of the NAD+ precursor nicotinamide in obesity-related heart failure with preserved ejection fraction.

Inhibition of Adipose Tissue Lipolysis Treats Obesity-Related HFpEF.

Phosphorylation of CRYAB induces a condensatopathy to worsen post-myocardial infarction left ventricular remodeling.

Caloric restriction and its mimetics in heart failure with preserved ejection fraction: mechanisms and therapeutic potential.

A surge in endogenous spermidine is essential for rapamycin-induced autophagy and longevity

Spermidine is essential for fasting-mediated autophagy and longevity

Lean ZSF1 rats in basic research on heart failure with preserved ejection fraction.

Antagonistic pleiotropy: the example of cardiac insulin-like growth factor signaling, which is essential in youth but detrimental in age

The impact of moderate endurance exercise on cardiac telomeres and cardiovascular remodeling in obese rats

miR-1183 Is a Key Marker of Remodeling upon Stretch and Tachycardia in Human Myocardium

Metabolic therapy for managing heart failure with preserved ejection fraction.

Basal oxidation of conserved cysteines modulates cardiac titin stiffness and dynamics.

Effects of Atrial Fibrillation on the Human Ventricle.

Effects of Atrial Fibrillation on the Human Ventricle

Acetylation and phosphorylation changes to cardiac proteins in experimental HFpEF due to metabolic risk reveal targets for treatment

Cardiac PI3K p110a attenuation delays aging and extends lifespan

Effects of Short Term Adiponectin Receptor Agonism on Cardiac Function and Energetics in Diabetic db/db Mice

Collaborators (19)

Senka Ljubojevic-Holzer

Claudio De Virgilio

Petra Büttner

Ines Martinez-Martin

Mahmoud Abdellatif

Carmen Suay-Corredera

Peter P Rainer

Markus Hoffmann

Akos Heinemann

Raffaele Nicastro

Markus Wallner

Anika Rajput Khokhar

Ulrich Stelzl

Kathrin Thedieck

María Mittelbrunn

Marinos Kallikourdis

Jihoon Nah

Cristina E Molina

Christoph Magnes

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NAD<sup>+</sup> repletion restores cardioprotective autophagy and mitophagy in obesity-associated heart failure by suppressing excessive trophic signaling.