Mahmoud Abdellatif

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Tenure Track Assistant Professor & Group Leader

Medical University of Graz

Austria

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About

Mahmoud Abdellatif is a Tenure Track Assistant Professor and Group Leader at the Medical University of Graz, Austria. His research focuses on cardiovascular health, particularly the effects of obesity, aging, and therapeutic interventions in heart failure. Recent publications include studies on the anticancer properties of aclarubicin, the role of NAD+ in cardioprotection, and mechanisms of aging related to cardiovascular diseases.

Recent Grants

Grant: Close

ÖKG Presidential Research Grant

Open Date: 2020-01-01

Close Date: 2022-01-01

Grant: Close

Basic Science Fellowship

Open Date: 2019-01-01

Close Date: 2019-01-01

Grant: Close

Staff mobility grant; Cardiovascular R&D unit, Porto Faculty of Medicine (Portugal)

Open Date: 2017-10-01

Close Date: 2017-10-01

Grant: Close

Staff mobility grant; Bayer Pharmaceuticals R&D Center (Wuppertal, Germany)

Open Date: 2017-04-01

Close Date: 2017-04-01

Grant: Close

PhD Fellowship (FWF standalone project: Cardioprotective Mechanisms of Spermidine

Open Date: 2015-01-01

Close Date: 2019-01-01

Articles (19)

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2022

Collaborators (14)

Simon Sedej

Associate Professor

Medical University of Graz

AUSTRIA

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Claudio De Virgilio

Full Professor

University of Fribourg

SWITZERLAND

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Petra Büttner

Head of Lab

Heart Center Leipzig at University of Leipzig

GERMANY

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Peter P Rainer

Associate Professor

Medical University of Graz

AUSTRIA

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Carlos Rodriguez Lopez

Profesor Asociado

University of Castilla-La Mancha

SPAIN

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Markus Hoffmann

Professor

University of Lübeck

GERMANY

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Raffaele Nicastro

University of Fribourg

SWITZERLAND

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Christoph Ruckenstuhl

Associate Professor/PhD

Graz University of Technology

AUSTRIA

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Rolf Breinbauer

Professor

Graz University of Technology

AUSTRIA

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Anika Rajput Khokhar

Charité - Universitätsmedizin Berlin

GERMANY

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Ulrich Stelzl

professor

Graz University of Technology

AUSTRIA

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Julie McMullen

MONASH UNIVERSITY

AUSTRALIA

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Jihoon Nah

Assistant Professor

Chungbuk National University

SOUTH KOREA

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Christoph Magnes

Head of Research Group

Joanneum Research

AUSTRIA

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Mahmoud Abdellatif

Research Interests

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About

Recent Grants

Articles (19)

Mechano-energetic uncoupling in heart failure.

NAD&lt;sup&gt;+&lt;/sup&gt; repletion restores cardioprotective autophagy and mitophagy in obesity-associated heart failure by suppressing excessive trophic signaling.

Autophagy is required for the therapeutic effects of the NAD+ precursor nicotinamide in obesity-related heart failure with preserved ejection fraction.

Caloric restriction and its mimetics in heart failure with preserved ejection fraction: mechanisms and therapeutic potential.

Acyl-CoA-binding protein as a driver of pathological aging

Potent immune-dependent anticancer effects of the non-cardiotoxic anthracycline aclarubicin

Obesity accelerates cardiovascular ageing

Inhibition of Adipose Tissue Lipolysis Treats Obesity-Related HFpEF

A surge in endogenous spermidine is essential for rapamycin-induced autophagy and longevity

Spermidine is essential for fasting-mediated autophagy and longevity

Anti-ageing interventions for the treatment of cardiovascular disease

Metabolic control of mitophagy

Lean ZSF1 rats in basic research on heart failure with preserved ejection fraction.

Antagonistic pleiotropy: the example of cardiac insulin-like growth factor signaling, which is essential in youth but detrimental in age

Hallmarks of cardiovascular ageing

High plasma concentrations of acyl‐coenzyme A binding protein (ACBP) predispose to cardiovascular disease: Evidence for a phylogenetically conserved proaging function of ACBP

Actionable autophagy checkpoints in cardiovascular ageing

Response by Sedej and Abdellatif to Letter Regarding Article, “Fine-Tuning Cardiac Insulin-Like Growth Factor 1 Receptor Signaling to Promote Health and Longevity”

Fine-Tuning Cardiac Insulin-Like Growth Factor 1 Receptor Signaling to Promote Health and Longevity

Collaborators (14)

Simon Sedej

Claudio De Virgilio

Petra Büttner

Peter P Rainer

Carlos Rodriguez Lopez

Markus Hoffmann

Raffaele Nicastro

Christoph Ruckenstuhl

Rolf Breinbauer

Anika Rajput Khokhar

Ulrich Stelzl

Julie McMullen

Jihoon Nah

Christoph Magnes

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NAD<sup>+</sup> repletion restores cardioprotective autophagy and mitophagy in obesity-associated heart failure by suppressing excessive trophic signaling.