Stefan Knapp

Goethe University Frankfurt

Germany

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Articles (20)

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2024

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2024

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2023

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2023

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2023

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2023

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2023

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2023

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2023

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2023

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2022

Collaborators (11)

Ioannis Kostakis

Associate Professor

GREECE

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Pavel Mykhailiuk

UKRAINE

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Dominique Schols

BELGIUM

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Pascal Heitel

GERMANY

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Florian Wittlinger

Eberhard Karls Universität Tübingen

GERMANY

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Markus Seeliger

Assistant Professor

Stony Brook University

UNITED STATES

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Matthias Gehringer

Eberhard Karls Universität Tübingen

GERMANY

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Wenxin Felix Zhu

University of Münster

GERMANY

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Valerio Consalvi

Sapienza University of Rome

ITALY

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Kristian Strømgaard

Københavns Universitet

DENMARK

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Andreas Joerger

Goethe University Frankfurt

GERMANY

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Stefan Knapp

Research Interests

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Articles (20)

Development of Highly Potent and Selective Covalent FGFR4 Inhibitors Based on S<sub>N</sub>Ar Electrophiles

Photosensitization enables Pauson-Khand–type reactions with nitrenes

Elimination of mutant SWI/SNF complexes by protein quality control: new opportunities targeting aggressive rhabdoid tumours

Splice variants of CK1α and CK1α-like: Comparative analysis of subcellular localization, kinase activity, and function in the Wnt signaling pathway

Chemogenomics for NR1 nuclear hormone receptors

Expanding the ligand spaces for E3 ligases for the design of protein degraders

Development of Potent Dual BET/HDAC Inhibitors via Pharmacophore Merging and Structure-Guided Optimization

Structure-Guided Design of a Highly Potent Partial RXR Agonist with Superior Physicochemical Properties

Leucettinibs, a Class of DYRK/CLK Kinase Inhibitors Inspired by the Marine Sponge Natural Product Leucettamine B

5-Iodotubercidin sensitizes cells to RIPK1-dependent necroptosis by interfering with NFκB signaling

Targeting the Alternative Vitamin E Metabolite Binding Site Enables Noncanonical PPARγ Modulation

Tracking the PROTAC degradation pathway in living cells highlights the importance of ternary complex measurement for PROTAC optimization

Design and Synthesis of Pyrazole-Based Macrocyclic Kinase Inhibitors Targeting BMPR2

Structure-Based Development of Isoform-Selective Inhibitors of Casein Kinase 1ε vs Casein Kinase 1δ

Mutation in the Common Docking Domain Affects MAP Kinase ERK2 Catalysis and Stability

Structural insights into a regulatory mechanism of FIR RRM1–FUSE interaction

Development of a Potent Cyclic Peptide Inhibitor of the nNOS/PSD-95 Interaction

Synthesis and Biological Evaluation of 2-Substituted Quinazolin-4(3H)-Ones with Antiproliferative Activities

Death by a thousand cuts through kinase inhibitor combinations that maximize selectivity and enable rational multitargeting

Resistance to kinase inhibition through shortened target engagement

Collaborators (11)

Ioannis Kostakis

Pavel Mykhailiuk

Dominique Schols

Pascal Heitel

Florian Wittlinger

Markus Seeliger

Matthias Gehringer

Wenxin Felix Zhu

Valerio Consalvi

Kristian Strømgaard

Andreas Joerger

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