Stefan Krimmer

Yale University

United States

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Articles (8)

Year:

2023

Year:

2022

Year:

2022

Year:

2022

Year:

2021

Year:

2021

Year:

2020

Year:

2020

Collaborators (7)

Krishna Mudumbi

Yale University

UNITED STATES

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Mark Lemmon

Alfred Gilman Professor and Co-Director

Yale University School of Medicine

UNITED STATES

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William Jorgensen

Yale University

UNITED STATES

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Joseph Schlessinger

Yale University

UNITED STATES

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Wei Mi

Assistant Professor

Yale University

UNITED STATES

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Sangwon Lee

Assistant Professor

Yale University School of Medicine

UNITED STATES

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Julian Tirado-Rives

Yale University

UNITED STATES

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Stefan Krimmer

Research Interests

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Articles (8)

Cryo-EM analyses of KIT and oncogenic mutants reveal structural oncogenic plasticity and a target for therapeutic intervention

Unveiling molecular insights into the mechanism of activation of oncogenic phosphoinositide 3-kinase mutants

Conversion of a False Virtual Screen Hit into Selective JAK2 JH2 Domain Binders Using Convergent Design Strategies

Insights on JAK2 Modulation by Potent, Selective, and Cell-Permeable Pseudokinase-Domain Ligands

Indoloxytriazines as binding molecules for the JAK2 JH2 pseudokinase domain and its V617F variant

Structural basis for ligand reception by anaplastic lymphoma kinase

Metadynamics as a postprocessing method for virtual screening with application to the pseudokinase domain of JAK2

Selective Janus Kinase 2 (JAK2) Pseudokinase Ligands with a Diaminotriazole Core

Collaborators (7)

Krishna Mudumbi

Mark Lemmon

William Jorgensen

Joseph Schlessinger

Wei Mi

Sangwon Lee

Julian Tirado-Rives

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