Stephan Gruber

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Associate Professor

University of Lausanne

Switzerland

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Stephan Gruber is an Associate Professor at the University of Lausanne, Switzerland. His research areas focus on bacterial chromosome segregation, DNA structures, and gene activation mechanisms. Recent publications include studies on the structural basis of DNA condensation and the role of ParB proteins in gene activation and chromosome segregation.

Recent Grants

Grant: Close

DNA Recruitment, Regulation & Function of SMC5/6

Open Date: 2017-07-01

Close Date: 2020-06-30

Grant: Close

Chromosomal Condensin Dynamics: From Local Loading to Global Architecture

Open Date: 2017-06-01

Close Date: 2022-05-31

Grant: Close

Untangling the Bacterial Chromosome: Condensin's Role in Sister Chromosome Separation and its Mechanisms

Open Date: 2010-11-01

Close Date: 2015-10-31

Grant: Close

HFSP Fellowship

Open Date: 2007-05-01

Close Date: 2010-04-30

Grant: Close

Molecular basis for chromosome organization and condensation in Bacillus subtilis

Open Date: 2007-05-01

Close Date: 2010-04-30

Articles (20)

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2025

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2022

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2021

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2021

Collaborators (7)

Jan Roelof van der Meer

Professor

University of Lausanne

SWITZERLAND

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Jeff Errington

University of Sydney

AUSTRALIA

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Cees Dekker

Professor at Delft University of Technology

Delft University of Technology

NETHERLANDS

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Young-Min Soh

National Institutes of Health

UNITED STATES

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Roman Barth

Delft University of Technology

NETHERLANDS

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Jacob Willem Jozef Kerssemakers

Delft University of Technology

NETHERLANDS

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Aleksandre Japaridze

Delft University of Technology

NETHERLANDS

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Stephan Gruber

Research Interests

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About

Recent Grants

Articles (20)

Orchestrated long-distance gene activation by a ParB-like BisD-CTP DNA clamp in low-frequency transfer competence development in Pseudomonas putida

Structure of a type II SMC Wadjet complex from Neobacillus vireti

4G cloning: rapid gene assembly for expression of multisubunit protein complexes in diverse hosts

Author Correction: Direct observation of a crescent-shape chromosome in expanded Bacillus subtilis cells

Direct observation of a crescent-shape chromosome in expanded Bacillus subtilis cells

Structural basis for plasmid restriction by SMC JET nuclease

Connecting the dots: key insights on ParB for chromosome segregation from single-molecule studies

DNA supercoiling enhances DNA condensation by ParB proteins

SMC-based immunity against extrachromosomal DNA elements

DNA segment capture by Smc5/6 holocomplexes

Dynamic ParB–DNA interactions initiate and maintain a partition condensate for bacterial chromosome segregation

VirB, a transcriptional activator of virulence in Shigella flexneri, uses CTP as a cofactor

DNA-measuring Wadjet SMC ATPases restrict smaller circular plasmids by DNA cleavage

Chromosome remodelling by SMC/Condensin in B. subtilis is regulated by monomeric Soj/ParA during growth and sporulation

A joint-ParB interface promotes Smc DNA recruitment

ParB proteins can bypass DNA-bound roadblocks via dimer-dimer recruitment

ParB proteins can bypass DNA-bound roadblocks via dimer-dimer recruitment

DNA tension-modulated translocation and loop extrusion by SMC complexes revealed by molecular dynamics simulations

Relief of ParB autoinhibition by parS DNA catalysis and recycling of ParB by CTP hydrolysis promote bacterial centromere assembly

Relief of ParB autoinhibition by parS DNA catalysis and recycling of ParB by CTP hydrolysis promote bacterial centromere assembly

Collaborators (7)

Jan Roelof van der Meer

Jeff Errington

Cees Dekker

Young-Min Soh

Roman Barth

Jacob Willem Jozef Kerssemakers

Aleksandre Japaridze

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