Stephen Cochrane

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Lecturer in Organic Chemistry

The Queen's University Belfast

United Kingdom

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Stephen Cochrane is a Lecturer in Organic Chemistry at Queen's University Belfast, UK. His research interests focus on antimicrobial peptides, synthetic methodologies for cyclic lipopeptides, and the biochemical mechanisms of antibiotic resistance. Recent publications include investigations into menaquinone-binding peptides and the development of novel antibiotic variants targeting resistant pathogens.

Recent Grants

Grant: Close

Mechanistic Studies on Glycolipid Flippases

Open Date: 2016-02-01

Close Date: 2020-01-01

Grant: Close

Structural and Mechanistic Studies on the Antimicrobial Lipopeptide Tridecaptin A1

Open Date: 2014-09-01

Close Date: 2015-11-01

Grant: Close

Synthesis of amino-vinyl cysteine containing antibiotics

Open Date: 2011-09-01

Close Date: 2014-09-01

Articles (18)

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2025

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2022

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2021

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2021

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2020

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2020

Collaborators (9)

Emilio J. Cocinero

Universidad del País Vasco (UPV/EHU)

SPAIN

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Andrew Giltrap

Lecturer

University of Technology, Sydney

AUSTRALIA

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Martin Caffrey

Trinity College Dublin

IRELAND

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Joseph Lorent

Assistant Professor

UCLouvain

BELGIUM

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Maik Derks

Eindhoven University of Technology

NETHERLANDS

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Callum Ives

Assistant Lecturer in Chemistry

Atlantic Technological University

IRELAND

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Sharon Huws

Professor and Director Research

The Queen's University Belfast

UNITED KINGDOM

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Joost Willemse

Facility manager / Assistant professor

Leiden University

NETHERLANDS

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Nathaniel I. Martin

Leiden University

NETHERLANDS

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Stephen Cochrane

Research Interests

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About

Recent Grants

Articles (18)

Lipid-Modulated, Graduated Inhibition of N-Glycosylation Pathway Priming Suggests Wide Tolerance of ER Proteostasis to Stress

Chemical diversification of polyprenyl quinones for mechanistic studies on menaquinone-binding peptide antibiotics

Hijacking the Electron Train: Menaquinone‐Binding Antimicrobial Peptides

A novel approach for the synthesis of the cyclic lipopeptide globomycin

A novel approach for the synthesis of the cyclic lipopeptide globomycin

Chemical diversification of polyprenyl quinones for mechanistic studies on menaquinone-binding peptide antibiotics

A classic antibiotic reimagined: Rationally designed bacitracin variants exhibit potent activity against vancomycin-resistant pathogens

Host defence peptide plectasin targets bacterial cell wall precursor lipid II by a calcium-sensitive supramolecular mechanism

Microbiome-derived antimicrobial peptides show therapeutic activity against the critically important priority pathogen, Acinetobacter baumannii

Computational design of cyclic peptide inhibitors of a bacterial membrane lipoprotein peptidase

Linearization of the Brevicidine and Laterocidine Lipopeptides Yields Analogues That Retain Full Antibacterial Activity

Targeting membrane-bound bacterial cell wall precursors: a tried and true antibiotic strategy in nature and the clinic

Synthesis and structure–activity relationship studies of N-terminal analogues of the lipopeptide antibiotics brevicidine and laterocidine

Binding Studies Reveal Phospholipid Specificity and Its Role in the Calcium-Dependent Mechanism of Action of Daptomycin

Undecaprenol kinase: Function, mechanism and substrate specificity of a potential antibiotic target

The tridecaptins: non-ribosomal peptides that selectively target Gram-negative bacteria

Observation of the Unbiased Conformers of Putative DNA-Scaffold Ribosugars

From plant to probe: semi-synthesis of labelled undecaprenol analogues allows rapid access to probes for antibiotic targets

Collaborators (9)

Emilio J. Cocinero

Andrew Giltrap

Martin Caffrey

Joseph Lorent

Maik Derks

Callum Ives

Sharon Huws

Joost Willemse

Nathaniel I. Martin

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