Stephen Muench

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Lecturer in Membrane Biology

University of Leeds

United Kingdom

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About

Stephen Muench is a Lecturer in Membrane Biology at the University of Leeds, UK. His research focuses on various aspects of membrane biology, including drug identification for epilepsy, lipid particle recognition in relation to atherosclerosis and cancer, and the implications of cryoEM sample preparation. Recent publications highlight his work on membrane transport, bioelectrochemistry, and the molecular mechanisms of potassium channels.

Recent Grants

Grant: Close

China Partnering Award: Emerging Approaches to Intracellular Signaling

Open Date: 2018-07-01

Close Date: 2022-06-30

Grant: Close

The role of closely-associated lipids in membrane protein structure and function

Open Date: 2018-06-30

Close Date: 2021-06-29

Grant: Close

Structural insights into small molecule activation of TRPC4/5 channels

Open Date: 2017-09-30

Close Date: 2020-09-29

Grant: Close

Time-resolved methodologies to provide both spatial and temporal resolution in Electron Microscopy

Open Date: 2017-09-24

Close Date: 2018-09-23

Grant: Close

Mass spectrometry infrastructure underpinning research into the molecular basis and biological mechanisms in health and disease

Open Date: 2017-09-01

Close Date: 2022-08-31

Articles (17)

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2020

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2020

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2020

Collaborators (16)

Annette F. Taylor

University of Sheffield

UNITED KINGDOM

Stephen Muench

Research Interests

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About

Recent Grants

Articles (17)

Membrane Transport Modulates the pH-Regulated Feedback of an Enzyme Reaction Confined within Lipid Vesicles

Solid-supported polymer–lipid hybrid membrane for bioelectrochemistry of a membrane redox enzyme

Identification of New KCNT1‐Epilepsy Drugs by In Silico, Cell, and Drosophila Modeling

Modified Lipid Particle Recognition: A Link Between Atherosclerosis and Cancer?

Untangling the effects of flexibility and the AWI in cryoEM sample preparation: A case study using KtrA

A molecular switch in RCK2 triggers sodium-dependent activation of KNa1.1 (KCNT1) potassium channels

CryoEM grid preparation: a closer look at advancements and impact of preparation mode and new approaches

Time resolved applications for Cryo-EM; approaches, challenges and future directions

A 2.2 Å cryoEM structure of a quinol-dependent NO Reductase shows close similarity to respiratory oxidases

Moving in the mesoscale: Understanding the mechanics of cytoskeletal molecular motors by combining mesoscale simulations with imaging

Maintaining the momentum in cryoEM for biological discovery

Recent developments in the structural characterisation of the IR and IGF1R: implications for the design of IR–IGF1R hybrid receptor modulators

Towards sub-millisecond cryo-EM grid preparation

On-grid and in-flow mixing for time-resolved cryo-EM

Human TRPC5 structures reveal interaction of a xanthine-based TRPC1/4/5 inhibitor with a conserved lipid binding site.

Structural Basis for Vascular Endothelial Growth Factor Receptor Activation and Implications for Disease Therapy

Cryo-EM Structure and Molecular Dynamics Analysis of the Fluoroquinolone Resistant Mutant of the AcrB Transporter from <i>Salmonella</i>

Collaborators (16)

Annette F. Taylor

Robin Bon

Michael Webb

Shervanthi Homer-Vanniasinkam

Lars Jeuken

Michelle Peckham

Robert Kay

Peter John Francis Henderson

Sreenivasan Ponnambalam

Rashid Hussain

Michael Ricos

Oliver Harlen

Rebecca F. Thompson

Daniel J. Read

David Beech

Katie Simmons

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