Stuart C Winter

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University of Oxford

United Kingdom

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Recent Grants

Grant: Open

PET-CT guided, symptom-based, patient-initiated surveillance versus clinical follow-up in advanced head neck cancer (PET NECK 2)

Open Date: 2020-11-30

Close Date: 2026-11-29

Grant: Close

Getting Recovery Right After Neck Dissection (GRRAND-F): Feasibility study to design a pragmatic randomised controlled trial.

Open Date: 2019-09-01

Close Date: 2021-08-31

Grant: Close

Validating the PredicTR treatment response classifier for oropharyngeal cancer (PredicTR 2)

Open Date: 2019-03-01

Close Date: 2021-02-28

Articles (18)

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2025

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2025

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2025

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2025

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2025

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2024

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2024

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2023

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2023

Purpose: While there are several prognostic classifiers, to date, there are no validated predictive models that inform treatment selection for oropharyngeal squamous cell carcinoma (OPSCC). Our aim was to develop clinical and/or biomarker predictive models for patient outcome and treatment escalation for OPSCC. Experimental Design: We retrospectively collated clinical data and samples from a consecutive cohort of OPSCC cases treated with curative intent at ten secondary care centers in United Kingdom and Poland between 1999 and 2012. We constructed tissue microarrays, which were stained and scored for 10 biomarkers. We then undertook multivariable regression of eight clinical parameters and 10 biomarkers on a development cohort of 600 patients. Models were validated on an independent, retrospectively collected, 385-patient cohort. Results: A total of 985 subjects (median follow-up 5.03 years, range: 4.73–5.21 years) were included. The final biomarker classifier, comprising p16 and survivin immunohistochemistry, high-risk human papillomavirus (HPV) DNA in situ hybridization, and tumor-infiltrating lymphocytes, predicted benefit from combined surgery + adjuvant chemo/radiotherapy over primary chemoradiotherapy in the high-risk group [3-year overall survival (OS) 63.1% vs. 41.1%, respectively, HR = 0.32; 95% confidence interval (CI), 0.16–0.65; P = 0.002], but not in the low-risk group (HR = 0.4; 95% CI, 0.14–1.24; P = 0.114). On further adjustment by propensity scores, the adjusted HR in the high-risk group was 0.34, 95% CI = 0.17–0.67, P = 0.002, and in the low-risk group HR was 0.5, 95% CI = 0.1–2.38, P = 0.384. The concordance index was 0.73. Conclusions: We have developed a prognostic classifier, which also appears to demonstrate moderate predictive ability. External validation in a prospective setting is now underway to confirm this and prepare for clinical adoption.

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2023

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2022

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2022

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2022

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2022

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2022

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2021

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2021

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2021

Collaborators (70)

Hisham Marwan

Associate Professor

University of Texas Medical Branch

UNITED STATES

Stuart C Winter

Research Interests

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Recent Grants

Articles (18)

The Use of Fluorescent Markers to Detect and Delineate Head and Neck Cancer: A Scoping Review

Multidisciplinary evidence-based consensus statements on salvage surgery for recurrent head and neck cancer (International Centre for Recurrent Head and Neck Cancer)

ctDNA to Predict Treatment Response in Head and Neck Squamous Cell Carcinoma: A Systematic Review

Circulating tumour DNA to augment PET-CT in determining clinical outcome after head and neck cancer treatment:

Investigating the requirement for nasogastric tube feeding following transoral robotic surgery for head and neck cancer in Oxford: a retrospective cohort study

Head and Neck Cancer: United Kingdom National Multidisciplinary Guidelines, Sixth Edition

New robotic platform for transoral robotic surgery: an IDEAL stage 0 study

Current management of xerostomia in head and neck cancer patients

Getting Recovery Right After Neck Dissection (GRRAND-F): Mixed-methods feasibility study to design a pragmatic randomised controlled trial

Developing and Validating a Multivariable Prognostic-Predictive Classifier for Treatment Escalation of Oropharyngeal Squamous Cell Carcinoma: The PREDICTR-OPC Study

Methodology for the development of National Multidisciplinary Management Recommendations using a multi-stage meta-consensus initiative

Using immersive technology and architectural design to assist head and neck cancer patients’ recovery from treatment: A focus group and technology acceptance study

Inclusion body myositis and dysphagia. Presentation, intervention and outcome at a swallowing clinic

Functional Outcomes Following Total Laryngectomy and Pharyngolaryngectomy: A 20-Year Single Center Study

Clinical outcomes following pharyngolaryngectomy reconstruction: a 20-year single centre study

Death following pulmonary complications of surgery before and during the SARS-CoV-2 pandemic

Global wealth disparities drive adherence to COVID-safe pathways in head and neck cancer surgery.

Clinicians' Views of Patient-initiated Follow-up in Head and Neck Cancer: a Qualitative Study to Inform the PETNECK2 Trial.

Collaborators (70)

Hisham Marwan

Mina Youssef

Ladislao Cayetano Paniagua

Michael Kerin

Mohamed Elshaer

Max Robinson

Paul Nankivell

Mark Corrigan

Thomas Curl-Roper

Ava Lorenc

Sarah E Lamb

Brenda F Narice

Pierpaolo Sileri

BALTASAR PÉREZ-SABORIDO

Gareth J. Thomas

Satheesh prabhu

Tom K Gallagher

Marcus Jepson

Panayiotis Kyzas

Ebba K Lindqvist

Sivakumar Gananadha

Jason C. Fleming

Balazs Banky

Shafaque Shaikh

Jane Wolstenholme

Markus Blaurock

Sajid Sainuddin

Mahmoud Loubani

Amanda Caroline Dawson

manu vatish

Akash Srinivasan

David C. Y. Tang

Florian N Loch

Gabrielle van Ramshorst

VALERIA TONINI

Nikolaos Machairas

Cristobal Langdon

Florence Cook

Clare Schilling

Luigi Rolli

Oladejo Olaleye

Lee Cooper

Stephanie Larcombe

Gemma Mancebo Moreno

Mark Gormley

Teresa Guerrero Urbano

Matthew Cooper

Kitty Hiu Fung Wong

Mae Chester-Jones

Simon Andreas Mueller

Daniel Field

Filipe Castro Borges

Marco Caricato

JUAN-CARLOS GOMEZ-ROSADO

Michael Grechenig