Susan Lees-Miller

Professor

University of Calgary

Canada

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Susan Lees-Miller is a Professor at the University of Calgary, Canada. Her research primarily focuses on DNA damage response mechanisms, particularly non-homologous end joining (NHEJ) and the role of DNA-PK as a master regulator. Recent articles authored by her explore structural insights into NHEJ and the mechanisms of double-strand break repair in human cells.

Articles (11)

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2023

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2023

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2022

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2021

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2021

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2021

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2020

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2020

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2020

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2020

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2020

Collaborators (2)

Yuan He

Associate Professor

Northwestern University

UNITED STATES

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Roger Greenberg

Professor

University of Pennsylvania

UNITED STATES

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Susan Lees-Miller

Research Interests

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Contact this professor

About

Articles (11)

Cryo-EM visualization of DNA-PKcs structural intermediates in NHEJ

How to fix DNA breaks: new insights into the mechanism of non-homologous end joining

A Genetic roadmap to the DNA damage response to genotoxic agents in human cells

Structural basis of long-range to short-range synaptic transition in NHEJ

Structural insights into the role of DNA-PK as a master regulator in NHEJ

Mechanism of efficient double-strand break repair by a long non-coding RNA.

The active DNA-PK holoenzyme occupies a tensed state in a staggered synaptic complex.

Uncovering DNA-PKcs ancient phylogeny, unique sequence motifs and insights for human disease.

Nocodazole-Induced Expression and Phosphorylation of Anillin and Other Mitotic Proteins Are Decreased in DNA-Dependent Protein Kinase Catalytic Subunit-Deficient Cells and Rescued by Inhibition of the Anaphase-Promoting Complex/Cyclosome with proTAME but Not Apcin.

Nocodazole-induced expression and phosphorylation of anillin and other mitotic proteins are decreased in DNA-dependent protein kinase catalytic subunit-deficient cells and rescued by inhibition of the anaphase-promoting complex/cyclosome with protame but not apcin

ATM-Deficient Cancers Provide New Opportunities for Precision Oncology.

Collaborators (2)

Yuan He

Roger Greenberg

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