Tadahaya Mizuno

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assistant professor

University of Tokyo

Japan

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About

Tadahaya Mizuno is an assistant professor at the University of Tokyo, Japan. His research focuses on the analysis of enzyme activity and proteoform alterations, as well as the characterization of extracellular vesicles and gene expression deconvolution. Recent articles include studies on single-molecule enzyme activity, CRISPR-gRNA barcoding, and toxicopathological image representation, contributing to advancements in drug effect prediction and immune cell trafficking analysis.

Recent Grants

Grant: Close

生物情報学、発生医学の活用による原因不明小児肝臓難病の病態発症分子基盤の解明

Open Date: 2020-10-27

Close Date: 2023-03-31

Grant: Close

Establishment of CNS barrier-targeted drug development based on generation of a new field, Barrier Systems Biology

Open Date: 2020-04-01

Close Date: 2023-03-31

Grant: Close

Pharmacokinetic study on transporters in the xenobiotic detoxification among the liver, small intestine and kidney

Open Date: 2020-04-01

Close Date: 2023-03-31

Grant: Close

ABC輸送体の機能増強による疾患治療実現に向けた創薬標的の同定法開発

Open Date: 2020-04-01

Close Date: 2023-03-31

Grant: Close

Development of lead optimization method using novel profile data analysis method

Open Date: 2019-06-28

Close Date: 2021-03-31

Articles (18)

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2025

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2021

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2020

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2020

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2020

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2020

Collaborators (4)

Yoshiki Miura

Juntendo University

JAPAN

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Toshiki Kurosawa

Assistant Professor

Teikyo University

JAPAN

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Kei Higuchi

Assistant Professor

Tokyo University of Pharmacy and Life Sciences

JAPAN

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Hisamitsu Hayashi

Associate Professor

University of Tokyo

JAPAN

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Tadahaya Mizuno

Research Interests

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About

Recent Grants

Articles (18)

Single-Molecule Enzyme Activity Analysis for Illuminating Pathological Proteoforms

Single-Molecule Oxidoreductase Activity Analysis for Activity-Based Diagnosis Based on Proteoform Alterations

Barcoding of small extracellular vesicles with CRISPR-gRNA enables comprehensive, subpopulation-specific analysis of their biogenesis and release regulators

GLDADec: marker-gene guided LDA modeling for bulk gene expression deconvolution

Rat deconvolution as knowledge miner for immune cell trafficking from toxicogenomics databases

Investigation of the usefulness of liver-specific deconvolution method by establishing a liver benchmark dataset

Investigation of latent representation of toxicopathological images extracted by CNN model for understanding compound properties in vivo

NRBdMF: A Recommendation Algorithm for Predicting Drug Effects Considering Directionality

Characterization of proteome profile data of chemicals based on data-independent acquisition MS with SWATH method

Intestinal Atp8b1 dysfunction causes hepatic choline deficiency and steatohepatitis

Investigation of a Data Split Strategy Involving the Time Axis in Adverse Event Prediction Using Machine Learning

Decomposition Profile Data Analysis for Deep Understanding of Multiple Effects of Natural Products

A randomized trial to examine the impact of food on pharmacokinetics of 4-phenylbutyrate and change in amino acid availability after a single oral administration of sodium 4-phenylbutyrarte in healthy volunteers

Current progress in identifying endogenous biomarker candidates for drug transporter phenotyping and their potential application to drug development

Functional Investigation of Solute Carrier Family 35, Member F2, in Three Cellular Models of the Primate Blood-Brain Barrier.

Decomposition profile data analysis of multiple drug effects identifies endoplasmic reticulum stress-inducing ability as an unrecognized factor

Interesting Properties of Profile Data Analysis in the Understanding and Utilization of the Effects of Drugs

Alteration in the Plasma Concentrations of Endogenous Organic Anion–Transporting Polypeptide 1B Biomarkers in Patients with Non–Small Cell Lung Cancer Treated with Paclitaxel

Collaborators (4)

Yoshiki Miura

Toshiki Kurosawa

Kei Higuchi

Hisamitsu Hayashi

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