Takashi Murayama

Juntendo Daigaku

Japan

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Articles (20)

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2025

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2024

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2021

Collaborators (12)

Takuro Numaga-Tomita

Associate professor

Shinshu University

JAPAN

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Haruo Ogawa

Associate Professor

Kyoto University

JAPAN

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Masahide Kikkawa

Professor

University of Tokyo

JAPAN

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Ki Ho Park

Assistant Professor

University of Virginia

UNITED STATES

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Kotaro Oyama

National Institutes for Quantum and Radiological Science and Technology

JAPAN

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Tomohiko Ai

JAPAN

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Ryosuke Ishida

Assistant Professor

Nagoya University

JAPAN

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Hiroyuki Kagechika

Tokyo Medical and Dental University

JAPAN

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Yoshinobu Manome

Jikei University School of Medicine

JAPAN

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Fumio Matsumura

Professor

Rutgers University - Busch Campus

UNITED STATES

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Takayoshi Inoue

JAPAN

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Yuko Wada

UNITED STATES

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Takashi Murayama

Research Interests

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Articles (20)

Development of selective RyR2 inhibitors with a pharmacophore containing a parabanic acid skeleton

Dantrolene inhibition of ryanodine receptor 1 carrying the severe malignant hyperthermia mutation Y522S visualized by cryo-EM

Carvedilol suppresses ryanodine receptor-dependent Ca2+ bursts in human neurons bearing PSEN1 variants found in early onset Alzheimer's disease.

Dual role of the S5 segment in type 1 ryanodine receptor channel gating

Myosin phosphatase targeting subunit1 controls localization and motility of Rab7‐containing vesicles: Is myosin phosphatase a cytoplasmic dynein regulator?

MG53’s non-physiologic interaction with insulin receptor: lack of effect on insulin-stimulated Akt phosphorylation in muscle, heart and liver tissues

Discovery and Structure–Activity Relationship of a Ryanodine Receptor 2 Inhibitor

Author Correction: Cryo-EM structures of ryanodine receptors and diamide insecticides reveal the mechanisms of selectivity and resistance

Cryo-EM structures of ryanodine receptors and diamide insecticides reveal the mechanisms of selectivity and resistance

An inherited life-threatening arrhythmia model established by screening randomly mutagenized mice

Drug development for the treatment of RyR1-related skeletal muscle diseases

Mice with R2509C-RYR1 mutation exhibit dysfunctional Ca2+ dynamics in primary skeletal myocytes

Molecular basis for gating of cardiac ryanodine receptor explains the mechanisms for gain- and loss-of function mutations

Heat-hypersensitive mutants of ryanodine receptor type 1 revealed by microscopic heating

A reconstituted depolarization-induced Ca2+ release platform for validation of skeletal muscle disease mutations and drug discovery

Cytosolic Ca2+-dependent Ca2+ release activity primarily determines the ER Ca2+ level in cells expressing the CPVT-linked mutant RYR2

Molecular mechanism of the severe MH/CCD mutation Y522S in skeletal ryanodine receptor (RyR1) by cryo-EM

Sudden death after inappropriate shocks of implantable cardioverter defibrillator in a catecholaminergic polymorphic ventricular tachycardia case with a novel RyR2 mutation

Loss-of-function mutations in cardiac ryanodine receptor channel cause various types of arrhythmias including long QT syndrome

The Ryanodine Receptor as a Sensor for Intracellular Environments in Muscles

Collaborators (12)

Takuro Numaga-Tomita

Haruo Ogawa

Masahide Kikkawa

Ki Ho Park

Kotaro Oyama

Tomohiko Ai

Ryosuke Ishida

Hiroyuki Kagechika

Yoshinobu Manome

Fumio Matsumura

Takayoshi Inoue

Yuko Wada

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