Tatu Pantsar

University of Eastern Finland

Finland

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Articles (11)

In Silico Evaluation of the Thr58-Associated Conserved Water with KRAS Switch-II Pocket Binders

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Year:

2023

Target Hopping from Protein Kinases to PXR: Identification of Small-Molecule Protein Kinase Inhibitors as Selective Modulators of Pregnane X Receptor from TüKIC Library

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Year:

2022

Decisive role of water and protein dynamics in residence time of p38α MAP kinase inhibitors

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Year:

2022

Addressing a Trapped High-Energy Water: Design and Synthesis of Highly Potent Pyrimidoindole-Based Glycogen Synthase Kinase-3β Inhibitors

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Year:

2021

Identification and characterization of novel splice variants of human farnesoid X receptor

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Year:

2021

Molecular Dynamics Simulations in Drug Discovery and Pharmaceutical Development

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Year:

2020

Discovery and Evaluation of Enantiopure 9H-pyrimido[4,5-b]indoles as Nanomolar GSK-3β Inhibitors with Improved Metabolic Stability.

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Year:

2020

Design and synthesis of novel fluorescently labeled analogs of vemurafenib targeting MKK4.

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Year:

2020

The autoinhibited state of MKK4: Phosphorylation, putative dimerization and R134W mutant studied by molecular dynamics simulations.

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Year:

2020

KRAS(G12C)-AMG 510 interaction dynamics revealed by all-atom molecular dynamics simulations.

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Year:

2020

Bioisosteric Replacement of Arylamide-Linked Spine Residues with N-Acylhydrazones and Selenophenes as a Design Strategy to Novel Dibenzosuberone Derivatives as Type I 1/2 p38α MAP Kinase Inhibitors.

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Year:

2020

Collaborators (5)

André Juffer

Research unit leader (associate professor level)/ Senior Researcher / Biocomputing coordinator

University of Oulu

FINLAND

Atefeh Saadabadi

Åbo Akademi University

FINLAND

Andrea Tarozzi

Full Professor

University of Bologna

ITALY

Pierre Koch

University of Regensburg

GERMANY

Eveline Lescrinier

Professor

KU Leuven

BELGIUM

Tatu Pantsar

Research Interests

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Contact this professor

Articles (11)

In Silico Evaluation of the Thr58-Associated Conserved Water with KRAS Switch-II Pocket Binders

Target Hopping from Protein Kinases to PXR: Identification of Small-Molecule Protein Kinase Inhibitors as Selective Modulators of Pregnane X Receptor from TüKIC Library

Decisive role of water and protein dynamics in residence time of p38α MAP kinase inhibitors

Addressing a Trapped High-Energy Water: Design and Synthesis of Highly Potent Pyrimidoindole-Based Glycogen Synthase Kinase-3β Inhibitors

Identification and characterization of novel splice variants of human farnesoid X receptor

Molecular Dynamics Simulations in Drug Discovery and Pharmaceutical Development

Discovery and Evaluation of Enantiopure 9H-pyrimido[4,5-b]indoles as Nanomolar GSK-3β Inhibitors with Improved Metabolic Stability.

Design and synthesis of novel fluorescently labeled analogs of vemurafenib targeting MKK4.

The autoinhibited state of MKK4: Phosphorylation, putative dimerization and R134W mutant studied by molecular dynamics simulations.

KRAS(G12C)-AMG 510 interaction dynamics revealed by all-atom molecular dynamics simulations.

Bioisosteric Replacement of Arylamide-Linked Spine Residues with N-Acylhydrazones and Selenophenes as a Design Strategy to Novel Dibenzosuberone Derivatives as Type I 1/2 p38α MAP Kinase Inhibitors.

Collaborators (5)

André Juffer

Atefeh Saadabadi

Andrea Tarozzi

Pierre Koch

Eveline Lescrinier

How do I reach out?

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Tatu Pantsar

Research Interests

Explore related searches

Contact this professor

Articles (11)

In Silico Evaluation of the Thr58-Associated Conserved Water with KRAS Switch-II Pocket Binders

Target Hopping from Protein Kinases to PXR: Identification of Small-Molecule Protein Kinase Inhibitors as Selective Modulators of Pregnane X Receptor from T&uuml;KIC Library

Decisive role of water and protein dynamics in residence time of p38α MAP kinase inhibitors

Addressing a Trapped High-Energy Water: Design and Synthesis of Highly Potent Pyrimidoindole-Based Glycogen Synthase Kinase-3β Inhibitors

Identification and characterization of novel splice variants of human farnesoid X receptor

Molecular Dynamics Simulations in Drug Discovery and Pharmaceutical Development

Discovery and Evaluation of Enantiopure 9H-pyrimido[4,5-b]indoles as Nanomolar GSK-3β Inhibitors with Improved Metabolic Stability.

Design and synthesis of novel fluorescently labeled analogs of vemurafenib targeting MKK4.

The autoinhibited state of MKK4: Phosphorylation, putative dimerization and R134W mutant studied by molecular dynamics simulations.

KRAS(G12C)-AMG 510 interaction dynamics revealed by all-atom molecular dynamics simulations.

Bioisosteric Replacement of Arylamide-Linked Spine Residues with N-Acylhydrazones and Selenophenes as a Design Strategy to Novel Dibenzosuberone Derivatives as Type I 1/2 p38α MAP Kinase Inhibitors.

Collaborators (5)

André Juffer

Atefeh Saadabadi

Andrea Tarozzi

Pierre Koch

Eveline Lescrinier

How do I reach out?

Meet Kite AI

Target Hopping from Protein Kinases to PXR: Identification of Small-Molecule Protein Kinase Inhibitors as Selective Modulators of Pregnane X Receptor from TüKIC Library