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Tetsuya Nagata

Tokyo Medical and Dental University

Japan

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Research Interests

Cell Biology

80%

Biochemistry

30%

Rna Biology

50%

Molecular Biology

40%

Genome Engineering

40%

Gene Therapy

30%

Dna Nanotechnology

30%

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Articles21

Pharmacokinetics and protein binding of cholesterol-conjugated heteroduplex oligonucleotide

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Year:

2025

Enhanced Accumulation of Heteroduplex Oligonucleotides in Dystrophin-Deficient Skeletal Muscles by Single Oligonucleotide-Loaded Unit Polyion Complexes

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Year:

2025

G-Quadruplex-Based Splice Switching as a Therapeutic Approach in Duchenne Muscular Dystrophy

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Year:

2025

Frequency of FGF14 intronic GAA repeat expansion in patients with multiple system atrophy and undiagnosed ataxia in the Japanese population

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Year:

2025

Effect of chemical modification on the exon-skipping activity of heteroduplex oligonucleotides.

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Year:

2025

Effects of local reduction of endogenous α-synuclein using antisense oligonucleotides on the fibril-induced propagation of pathology through the neural network in wild-type mice

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Year:

2024

Heteroduplex oligonucleotide technology boosts oligonucleotide splice switching activity of morpholino oligomers in a Duchenne muscular dystrophy mouse model.

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Year:

2024

[Current Landscape of Tofersen in SOD-1-associated Amyotrophic Lateral Sclerosis].

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Year:

2024

DNA/RNA heteroduplex technology with cationic oligopeptide reduces class-related adverse effects of nucleic acid drugs.

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Year:

2024

Favorable efficacy and reduced acute neurotoxicity by antisense oligonucleotides with 2',4'-BNA/LNA with 9-(aminoethoxy)phenoxazine.

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Year:

2024

Effects of combinations of gapmer antisense oligonucleotides on the target reduction

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Year:

2023

Regulation of activated microglia and macrophages by systemically administered DNA/RNA heteroduplex oligonucleotides

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Year:

2022

The Role of Long Noncoding RNA MALAT1 in Diabetic Polyneuropathy and the Impact of Its Silencing in the Dorsal Root Ganglion by a DNA/RNA Heteroduplex Oligonucleotide

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Year:

2022

Systemic DNA/RNA heteroduplex oligonucleotide administration for regulating the gene expression of dorsal root ganglion and sciatic nerve

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Year:

2022

DNA/RNA heteroduplex oligonucleotide technology for regulating lymphocytes in vivo.

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Year:

2021

Cholesterol-functionalized DNA/RNA heteroduplexes cross the blood-brain barrier and knock down genes in the rodent CNS.

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Year:

2021

Effective silencing of miR-126 after ischemic stroke by means of intravenous α-tocopherol-conjugated heteroduplex oligonucleotide in mice.

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Year:

2021

Short DNA/RNA heteroduplex oligonucleotide interacting proteins are key regulators of target gene silencing.

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Year:

2021

Structural tuning of oligonucleotides for enhanced blood circulation properties of unit polyion complexes prepared from two-branched poly(ethylene glycol)-block-poly(l-lysine).

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Year:

2021

2',4'-BNA/LNA with 9-(2-Aminoethoxy)-1,3-diaza-2-oxophenoxazine Efficiently Forms Duplexes and Has Enhanced Enzymatic Resistance*.

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Year:

2020

Efficient Gene Suppression by DNA/DNA Double-Stranded Oligonucleotide In Vivo.

Article Link

Year:

2020

Collaborators10

Takanori Yokota

Tokyo Medical and Dental University

JAPAN

Kensuke Ihara

Tokyo Medical and Dental University

JAPAN

Masaki Ohyagi

Institute of Science Tokyo

JAPAN

Toshiyuki Kakumoto

University of Tokyo Hospital

JAPAN

Kotaro Yoshioka

Project Assistant Professor

Tokyo Medical and Dental University

JAPAN

Mitsuru NAITO

University of Tokyo

JAPAN

Fumika Sakaue

Research Assistant Professor

Tokyo Medical and Dental University

JAPAN

Syunsuke Yamamoto

Taisho Pharmaceutical (Japan)

JAPAN

Yo Mabuchi

Fujita Health University

JAPAN

Rintaro Hara

Project Junior Associate Professor

Tokyo Medical and Dental University

JAPAN

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