Thomas H. Sharp

Leiden University Medical Center

Netherlands

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Articles (14)

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2025

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2025

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2025

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2024

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2024

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2024

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2022

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2020

Collaborators (6)

vered raz

Associate Professor

Leiden University Medical Center

NETHERLANDS

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Leendert Trouw

Professor

Leiden University Medical Center

NETHERLANDS

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Paul J. Hensbergen

Leiden University Medical Center

NETHERLANDS

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Ferenc Scheeren

Leiden University Medical Center

NETHERLANDS

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Alexander Kros

Leiden University

NETHERLANDS

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jean-christophe Bourdon

Director of Research, . Senior lecturer

University of Dundee

UNITED KINGDOM

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Thomas H. Sharp

Research Interests

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Articles (14)

Polyalanine Expansion in PABPN1 Alters the Structure and Dynamics of Its Nuclear Aggregates in Differentiated Muscle Cells

Inducing Cancer Cell Killing Using DNA Nanostructure-Mediated Superclustering of Death Receptors

Modulation of immunoglobulin G oligomerization by variable domain glycans

Structural basis for surface activation of the classical complement cascade by the short pentraxin C-reactive protein

Engineering Agonistic Bispecifics to Investigate the Influence of Distance on Surface-Mediated Complement Activation

Selection and characterization of a peptide-based complement modulator targeting C1 of the innate immune system

DNA Nanostructure-Templated Antibody Complexes Provide Insights into the Geometric Requirements of Human Complement Cascade Activation

Building a super-resolution fluorescence cryomicroscope

Liquid crystalline inverted lipid phases encapsulating siRNA enhance lipid nanoparticle mediated transfection

Targeted complement inhibition using bispecific antibodies that bind local antigens and endogenous complement regulators

Germline variant affecting p53β isoforms predisposes to familial cancer

Streamlining segmentation of cryo-electron tomography datasets with Ais

PTX3 structure determination using a hybrid cryoelectron microscopy and AlphaFold approach offers insights into ligand binding and complement activation.

Carbamylation reduces the capacity of IgG for hexamerization and complement activation

Collaborators (6)

vered raz

Leendert Trouw

Paul J. Hensbergen

Ferenc Scheeren

Alexander Kros

jean-christophe Bourdon

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