Thomas Harrison

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United Kingdom

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Recent Grants

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NIHR Global Health Group on HIV-associated Fungal Infections

Open Date: 2022-08-01

Close Date: 2026-07-01

Grant: Close

Fluconazole plus flucytosine vs fluconazole alone for cryptococcal antigen-positive patients identified through screening: A randomised trial

Open Date: 2021-04-01

Close Date: 2025-04-01

Grant: Close

Improved flucytosine formulation for the treatment of meningitis in advanced HIV disease

Open Date: 2020-07-01

Close Date: 2024-12-01

Grant: Close

High Dose AMBISOME on a Fluconazole Backbone for Cryptococcal Meningitis Induction Therapy in sub-Saharan Africa: A Randomized Controlled Trial.

Open Date: 2017-01-01

Close Date: 2020-12-01

Grant: Close

Clinical PhD Programme in Global Health with LSHTM, UCL, QMUL, Kings, SGUL, and Brighton and Sussex Med School

Open Date: 2017-01-01

Close Date: 2021-01-01

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Collaborators (10)

Alistair JP Brown

Professor & Co-Director

University of Exeter

UNITED KINGDOM

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Joshua Rhein

University of Minnesota

UNITED STATES

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William Hope

University of Liverpool

UNITED KINGDOM

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Alan Pittman

University College London

UNITED KINGDOM

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Assistant Professor

University of California, San Francisco

UNITED STATES

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Thomas Harrison

Research Interests

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Recent Grants

Articles (28)

Relative contribution of pharmacokinetics and immune signatures to clinical outcomes in patients with HIV-associated cryptococcal meningitis

Author Correction: Risk-stratified treatment for drug-susceptible pulmonary tuberculosis

A composite subunit vaccine confers full protection against Buruli ulcer disease in the mouse footpad model of Mycobacterium ulcerans infection

Causes of HIV-related CNS infection in Cameroon, Malawi, and Tanzania: epidemiological findings from the DREAMM HIV-related CNS implementation study

Comparative analysis of glucuronoxylomannogalactan (GXMGal) and glucuronoxylomannan (GXM) antibody responses and their associations with cryptococcal disease status in people living with HIV

Epstein–Barr virus and cytomegalovirus co-infections and mortality risk in patients with HIV-associated cryptococcal meningitis: a post-hoc analysis of a prospective nested cohort in the AMBITION-cm randomised controlled trial

Ex Vivo Host Transcriptomics During Cryptococcus neoformans, Cryptococcus gattii, and Candida albicans Infection of Peripheral Blood Mononuclear Cells From South African Volunteers.

Household economic impact of HIV‐associated cryptococcal meningitis in five countries in Southern and Eastern Africa

Immunophenotyping of apparently immunocompetent hosts with cryptococcosis reveals IL-17 deficiency as a unifying susceptibility factor

Personalised risk-prediction tools for cryptococcal meningitis mortality to guide treatment stratification in sub-Saharan Africa: a prognostic modelling study based on pooled analysis of two randomised controlled trials

Global guideline for the diagnosis and management of cryptococcosis

Development and validation of quantitative PCR assays for HIV-associated cryptococcal meningitis in sub-Saharan Africa: a diagnostic accuracy study.

Integrated management of cryptococcal meningitis and concurrent opportunistic infections to improve outcomes in advanced HIV disease: a randomised strategy trial.

Optimizing the Treatment of Invasive Candidiasis-A Case for Combination Therapy.

Heightened Efficacy of Anidulafungin When Used in Combination with Manogepix or 5-Flucytosine against Candida auris In Vitro

Population pharmacokinetics and CSF penetration of flucytosine in adults with HIV-associated cryptococcal meningoencephalitis.

Presacral malakoplakia presenting as foot drop: a case report.

Genetic diversity and microevolution in clinical Cryptococcus isolates from Cameroon.

HIV and fungal priority pathogens.

Mucosal and systemic immune responses after a single intranasal dose of nanoparticle and spore-based subunit vaccines in mice with pre-existing lung mycobacterial immunity.

Pathways to care with HIV-associated cryptococcal meningitis in Botswana and Uganda: Findings from a qualitative methods study.

Cost-effectiveness of single, high-dose, liposomal amphotericin regimen for HIV-associated cryptococcal meningitis in five countries in sub-Saharan Africa: an economic analysis of the AMBITION-cm trial

Genomic Variation across a Clinical Cryptococcus Population Linked to Disease Outcome

Cerebrospinal fluid cytokine and chemokine patterns correlate with prognosis of HIV-uninfected cryptococcal meningitis: A prospective observational study.

Cryptococcal Antigenemia in Advanced HIV: Pathophysiology, Epidemiology and Clinical Implications.

Decision making in a clinical trial for a life-threatening illness: Therapeutic expectation, not misconception.

High concordance in plasma and CSF HIV-1 drug resistance mutations despite high cases of CSF viral escape in individuals with HIV-associated cryptococcal meningitis in Botswana.

How applicable is the single-dose AMBITION regimen for HIV-associated cryptococcal meningitis to high-income settings?

Collaborators (10)

Alistair JP Brown

Joshua Rhein

William Hope

Alan Pittman

David Boulware

Louis W Niessen

Katharine Stott

Moses Kelly Kumwenda

Síle Molloy

Patrick Phillips

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