Thomas Michaels

Assistant Professor

ETH Zürich

Switzerland

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About

Thomas Michaels is an Assistant Professor at ETH Zurich in Switzerland. His research focuses on the dynamics of multicellular aging, protein aggregation, and chemical reactions regulated by phase-separated condensates. Recent articles by Dr. Michaels explore topics such as self-replication in protein aggregation and the mechanisms underlying amyloid formation and enzymatic reactions within phase-separated environments.

Articles (17)

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2025

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2023

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2022

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2022

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2021

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2021

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2021

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2021

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2021

Collaborators (16)

Tuomas Knowles

Professor of Physical Chemistry and Biophysics

University of Cambridge

UNITED KINGDOM

Thomas Michaels

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Articles (17)

Fisher Information and the Dynamics of Multicellular Ageing

Cell-guiding microporous hydrogels by photopolymerization-induced phase separation

General integrated rate law for complex self-assembly reactions reveals the mechanism of amyloid-beta coaggregation

Physical limits to acceleration of enzymatic reactions inside phase-separated compartments

Self-replication of A β 42 aggregates occurs on small and isolated fibril sites

Chemical reactions regulated by phase-separated condensates

Amyloid formation as a protein phase transition

Spontaneous nucleation and fast aggregate-dependent proliferation of α-synuclein aggregates within liquid condensates at neutral pH

Enhanced potency of aggregation inhibitors mediated by liquid condensates

Uncovering the universality of self-replication in protein aggregation and its link to disease

Adsorption free energy predicts amyloid protein nucleation rates

Kinetic profiling of therapeutic strategies for inhibiting the formation of amyloid oligomers

Deformable and Robust Core–Shell Protein Microcapsules Templated by Liquid–Liquid Phase‐Separated Microdroplets

Feedback control of protein aggregation

Scaling analysis reveals the mechanism and rates of prion replication in vivo

Kinetic analysis reveals that independent nucleation events determine the progression of polyglutamine aggregation in C. elegans

The cusp of an apple

Collaborators (16)

Tuomas Knowles

Ralph Müller

Daniele Vigolo

Yi Shen

Michele Vendruscolo

Maarten Hardenberg

Margherita Bernero

Jeremy Schmit

David Klenerman

Daoyuan Qian

Mario Nuvolone

Daniel E. Otzen

Maria Andreasen

Steve Matthews

Andela Saric

Sara Linse

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