Tuomas Knowles

Professor of Physical Chemistry and Biophysics

University of Cambridge

United Kingdom

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About

Tuomas Knowles is a Professor of Physical Chemistry and Biophysics at the University of Cambridge, United Kingdom. His research focuses on understanding the molecular interactions involved in protein aggregation and biophysics, as demonstrated in his recent articles. His work includes exploring conformational transitions in tau proteins, the kinetics of protein aggregation, and the fundamental interactions within biomolecular condensates.

Articles (30)

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2025

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2023

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2023

Collaborators (18)

Celine Galvagnion

Københavns Universitet

DENMARK

Tuomas Knowles

Research Interests

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About

Articles (30)

Nanoscale profiling of evolving intermolecular interactions in ageing FUS condensates

Transforming an ATP-dependent enzyme into a dissipative, self-assembling system

Kinetics of seeded protein aggregation: Theory and application

Global kinetic model of lipid-induced α -synuclein aggregation and its inhibition by small molecules

Optofluidic Waveguides for the Label-Free Study of Silk Protein Aggregates

Direct Observation of the Conformational Transitions in Tau and Their Correlation with Phase Behavior

Transcript Identification Using Arrayed Hydrogels With TrapFISH

A Charge-Driven Strategy for Covalent Modification and Modulation of Biomolecular Condensates

A single fibril study reveals that ApoE inhibits the elongation of Aβ42 fibrils in an isoform-dependent manner

Aggregation of α-synuclein splice isoforms through a phase separation pathway

Unraveling the Structure and Dynamics of Ac-PHF6-NH2 Tau Segment Oligomers

Formation of Nanofibrillar Self-Healing Hydrogels Using Antimicrobial Peptides

Dominance analysis to assess solute contributions to multicomponent phase equilibria

Thermodynamic profiles for cotranslational trigger factor substrate recognition

Protein Condensate Atlas from predictive models of heteromolecular condensate composition

The role of shear forces in primary and secondary nucleation of amyloid fibrils

Biomolecular condensates with complex architectures via controlled nucleation

Aβ Oligomer Dissociation Is Catalyzed by Fibril Surfaces

Polysaccharide functionalization reduces lipid vesicle stiffness

Solutes unmask differences in clustering versus phase separation of FET proteins

Theoretical and Data-Driven Approaches for Biomolecular Condensates

Amyloid formation as a protein phase transition

Formation of Protein Nanoparticles in Microdroplet Flow Reactors

Microfluidic antibody affinity profiling of alloantibody-HLA interactions in human serum

Kinetic Analysis Reveals the Role of Secondary Nucleation in Regenerated Silk Fibroin Self-Assembly

Selenium Silk Nanostructured Films with Antifungal and Antibacterial Activity

Spatially non-uniform condensates emerge from dynamically arrested phase separation

A Kinetic Map of the Influence of Biomimetic Lipid Model Membranes on Aβ42 Aggregation

Structure-Based Discovery of Small-Molecule Inhibitors of the Autocatalytic Proliferation of α-Synuclein Aggregates

Amyloids and protein aggregation

Collaborators (18)

Celine Galvagnion

Vasilis Kosmoliaptsis

Sarah Teichmann

Michele Vendruscolo

Thomas Michaels

Anne Wentink

Anouk Rijs

Rohit Pappu

Max Lindberg

Rosana Collepardo-Guevara

Francesco Simone Ruggeri

Jan van Hest

Daoyuan Qian

Alexander Buell

Andela Saric

John Christodoulou

Sara Linse

Fengbin Wang

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