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Thomas O'Neill

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Helmholtz Zentrum München Deutsches Forschungszentrum für Umwelt und Gesundheit

Germany

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Functional role of MALT1 paracaspase activity in innate immune cells

Open Date: 2026-01-01

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Articles (11)

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2026

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2023

Collaborators (6)

Jan Kranich

Group Leader

Ludwig-Maximilians-Universität München

GERMANY

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Daniel Krappmann

Director Signaling and Translation

Helmholtz Zentrum München Deutsches Forschungszentrum für Umwelt und Gesundheit

GERMANY

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Ingo Schmitz

Professor

Ruhr-Universität Bochum

GERMANY

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Vigo Heissmeyer

Professor

Ludwig-Maximilians-Universität München

GERMANY

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Marcus Conrad

Distinguished Professor

Tohoku University

JAPAN

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Reinhard Obst

Lecturer

Ludwig-Maximilians-Universität München

GERMANY

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Thomas O'Neill

Research Interests

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Recent Grants

Articles (11)

MALT1 alternative splicing – a molecular rheostat for balancing immune activation and homeostasis

Systematic identification of pan-cancer single-gene expression biomarkers in drug high-throughput screens

Strong constitutive NF-κB signaling in B cells drives SLL/CLL-like lymphomagenesis and overcomes microenvironmental dependencies

MALT1 inhibitor MI-2 induces ferroptosis by direct targeting of GPX4.

LUBAC modulates CBM complex functions downstream of TRAF6 in T cells

An updated patent review of MALT1 inhibitors (2021-present)

Reciprocal regulation of mTORC1 signaling and ribosomal biosynthesis determines cell cycle progression in activated T cells

MALT1 substrate cleavage: what is it good for?

Unrestrained cleavage of Roquin-1 by MALT1 induces spontaneous T cell activation and the development of autoimmunity.

Function and targeting of MALT1 paracaspase in cancer

TRAF6 controls T cell homeostasis by maintaining the equilibrium of MALT1 scaffolding and protease functions

Collaborators (6)

Jan Kranich

Daniel Krappmann

Ingo Schmitz

Vigo Heissmeyer

Marcus Conrad

Reinhard Obst

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