Thorsten Lehr

Professor Clinical Pharmacy

Saarland University

Germany

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Research Interests

Pharmacology

100%

Pharmacotherapy

80%

Pharmacokinetic

60%

Pharmacometrics

50%

Covid-19

40%

Dose Optimization

30%

Cytochrome P450

30%

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Articles16

Personalized Chronomodulated 5‐Fluorouracil Treatment: A Physiologically‐Based Pharmacokinetic Precision Dosing Approach for Optimizing Cancer Therapy

Article Link

Year:

2024

A physiologically‐based pharmacokinetic precision dosing approach to manage dasatinib drug–drug interactions

Article Link

Year:

2024

Physiologically based pharmacokinetic modeling of imatinib and N‐desmethyl imatinib for drug–drug interaction predictions

Article Link

Year:

2024

Physiologically Based Pharmacokinetic Modeling of Bergamottin and 6,7‐Dihydroxybergamottin to Describe CYP3A4 Mediated Grapefruit‐Drug Interactions

Article Link

Year:

2023

A Physiologically Based Pharmacokinetic Model of Ketoconazole and Its Metabolites as Drug–Drug Interaction Perpetrators

Article Link

Year:

2023

Significant impact of time-of-day variation on metformin pharmacokinetics

Article Link

Year:

2023

Motivations for Adolescent COVID-19 Vaccination: A Comparative Study of Adolescent and Caregiver Perspectives in Germany

Article Link

Year:

2023

Pharmacometric Modeling of the Impact of Azelastine Nasal Spray on SARS-CoV-2 Viral Load and Related Symptoms in COVID-19 Patients

Article Link

Year:

2022

Problematic Internet Use among Adolescents 18 Months after the Onset of the COVID-19 Pandemic

Article Link

Year:

2022

A Physiologically Based Pharmacokinetic and Pharmacodynamic Model of the CYP3A4 Substrate Felodipine for Drug–Drug Interaction Modeling

Article Link

Year:

2022

Mental Health and Health-Related Quality of Life in German Adolescents after the Third Wave of the COVID-19 Pandemic

Article Link

Year:

2022

Physiologically Based Pharmacokinetic (PBPK) Modeling of Clopidogrel and Its Four Relevant Metabolites for CYP2B6, CYP2C8, CYP2C19, and CYP3A4 Drug–Drug–Gene Interaction Predictions

Article Link

Year:

2022

A Novel Approach for Quantifying the Pharmacological Activity of T-Cell Engagers Utilizing In Vitro Time Course Experiments and Streamlined Data Analysis

Article Link

Year:

2022

Does the circulating ketoconazole metabolite N-deacetyl ketoconazole contribute to the drug-drug interaction potential of the parent compound?

Article Link

Year:

2022

Human papillomavirus vaccination of girls in the German model region Saarland: Insurance data-based analysis and identification of starting points for improving vaccination rates

Article Link

Year:

2022

In Vitro–In Silico Modeling of Caffeine and Diclofenac Permeation in Static and Fluidic Systems with a 16HBE Lung Cell Barrier

Article Link

Year:

2022

Collaborators7

Robert Dallmann

Associate Professor

University of Warwick

UNITED KINGDOM

Johanna Weiss

University Hospital Heidelberg

GERMANY

Uwe Fuhr

University of Cologne, Faculty of Medicine and University Hospital Cologne

GERMANY

Folke Brinkmann

GERMANY

Henk-Jan Guchelaar

Leiden University Medical Center

NETHERLANDS

Jens Peter Klussmann

Professor and Chairman

GERMANY

Walter E. Haefeli

GERMANY

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Thorsten Lehr

Professor Clinical Pharmacy

How do I reach out?

Contact this professor

Research Interests

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Articles16

Personalized Chronomodulated 5‐Fluorouracil Treatment: A Physiologically‐Based Pharmacokinetic Precision Dosing Approach for Optimizing Cancer Therapy

A physiologically‐based pharmacokinetic precision dosing approach to manage dasatinib drug–drug interactions

Physiologically based pharmacokinetic modeling of imatinib and N‐desmethyl imatinib for drug–drug interaction predictions

Physiologically Based Pharmacokinetic Modeling of Bergamottin and 6,7‐Dihydroxybergamottin to Describe CYP3A4 Mediated Grapefruit‐Drug Interactions

A Physiologically Based Pharmacokinetic Model of Ketoconazole and Its Metabolites as Drug–Drug Interaction Perpetrators

Significant impact of time-of-day variation on metformin pharmacokinetics

Motivations for Adolescent COVID-19 Vaccination: A Comparative Study of Adolescent and Caregiver Perspectives in Germany

Pharmacometric Modeling of the Impact of Azelastine Nasal Spray on SARS-CoV-2 Viral Load and Related Symptoms in COVID-19 Patients

Problematic Internet Use among Adolescents 18 Months after the Onset of the COVID-19 Pandemic

A Physiologically Based Pharmacokinetic and Pharmacodynamic Model of the CYP3A4 Substrate Felodipine for Drug–Drug Interaction Modeling

Mental Health and Health-Related Quality of Life in German Adolescents after the Third Wave of the COVID-19 Pandemic

Physiologically Based Pharmacokinetic (PBPK) Modeling of Clopidogrel and Its Four Relevant Metabolites for CYP2B6, CYP2C8, CYP2C19, and CYP3A4 Drug&ndash;Drug&ndash;Gene Interaction Predictions

A Novel Approach for Quantifying the Pharmacological Activity of T-Cell Engagers Utilizing In Vitro Time Course Experiments and Streamlined Data Analysis

Does the circulating ketoconazole metabolite N-deacetyl ketoconazole contribute to the drug-drug interaction potential of the parent compound?

Human papillomavirus vaccination of girls in the German model region Saarland: Insurance data-based analysis and identification of starting points for improving vaccination rates

In Vitro–In Silico Modeling of Caffeine and Diclofenac Permeation in Static and Fluidic Systems with a 16HBE Lung Cell Barrier

Collaborators7

Robert Dallmann

Johanna Weiss

Uwe Fuhr

Folke Brinkmann

Henk-Jan Guchelaar

Jens Peter Klussmann

Walter E. Haefeli

How do I reach out?

Physiologically Based Pharmacokinetic (PBPK) Modeling of Clopidogrel and Its Four Relevant Metabolites for CYP2B6, CYP2C8, CYP2C19, and CYP3A4 Drug–Drug–Gene Interaction Predictions