Tomáš Macháček

Assistant Professor

Charles University

Czech Republic

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Tomáš Macháček is an Assistant Professor at Charles University in the Czech Republic. His research focuses on molecular detection and immune response to helminths, as well as the pathology associated with various parasitic infections. Recent publications include studies on the effects of Toxocara canis on Alzheimer’s disease pathology and the immunological implications of schistosomes and tapeworms in murine models.

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2020

Collaborators (6)

Libor Mikes

Assistant Professor

Charles University

CZECH REPUBLIC

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Petr Horák

Charles University

CZECH REPUBLIC

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Jan Novák

Charles University, First Faculty of Medicine

CZECH REPUBLIC

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Jan Dvorak

Medical University of Vienna

AUSTRIA

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Michael Trauner

Professor of Medicine and Chair of Gastroenterology and Hepatology

Medical University of Vienna

AUSTRIA

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Daniel Rosel

Associate Professor

Charles University, Faculty of Science

CZECH REPUBLIC

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Tomáš Macháček

Research Interests

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About

Articles (24)

Molecular detection and identification of Trichobilharzia: development of a LAMP, qPCR, and multiplex PCR toolkit

No evidence of Alzheimer’s disease pathology in mice infected with Toxocara canis

No evidence of Alzheimer's disease pathology in mice infected with <i>Toxocara canis</i>

The avian schistosome Trichobilharzia franki in mice: Migration, pathogenicity, and the host immune response

Winners vs. losers: Schistosoma mansoni intestinal and liver eggs exhibit striking differences in gene expression and immunogenicity

The neurotropic schistosome vs experimental autoimmune encephalomyelitis: are there any winners?

Suppression of the growth and metastasis of mouse melanoma by <i>Taenia crassiceps</i> and <i>Mesocestoides corti</i> tapeworms

Winners vs. losers: <i>Schistosoma mansoni</i> intestinal and liver eggs exhibit striking differences in gene expression and immunogenicity

Utilization of a highly adaptable murine air pouch model for minimally invasive testing of the inflammatory potential of biomaterials

Suppression of the growth and metastasis of mouse melanoma by Taenia crassiceps and Mesocestoides corti tapeworms

MrgprA3 neurons drive cutaneous immunity against helminths through selective control of myeloid-derived IL-33

MrgprA3 neurons drive cutaneous immunity against helminths through selective control of myeloid-derived IL-33

Utilization of a highly adaptable murine air pouch model for minimally invasive testing of the inflammatory potential of biomaterials

Bsep/Abcb11 knockout ameliorates Schistosoma mansoni liver pathology by reducing parasite fecundity.

Bsep/Abcb11 knockout ameliorates Schistosoma mansoni liver pathology by reducing parasite fecundity

Infectious origin of Alzheimer’s disease: Amyloid beta as a component of brain antimicrobial immunity

Infectious origin of Alzheimer's disease: Amyloid beta as a component of brain antimicrobial immunity

Toxocara canis infection worsens the course of experimental autoimmune encephalomyelitis in mice

Mechanisms of the host immune response and helminth-induced pathology during Trichobilharzia regenti (Schistosomatidae) neuroinvasion in mice

Comparative proteome analysis of the tegument of male and female adult Schistosoma mansoni

Isoforms of Cathepsin B1 in Neurotropic Schistosomula of Trichobilharzia regenti Differ in Substrate Preferences and a Highly Expressed Catalytically Inactive Paralog Binds Cystatin

Isoforms of Cathepsin B1 in Neurotropic Schistosomula of Trichobilharzia regenti Differ in Substrate Preferences and a Highly Expressed Catalytically Inactive Paralog Binds Cystatin

Nitric oxide debilitates the neuropathogenic schistosome Trichobilharzia regenti in mice, partly by inhibiting its vital peptidases

The peripheral immune response of mice infected with a neuropathogenic schistosome

Collaborators (6)

Libor Mikes

Petr Horák

Jan Novák

Jan Dvorak

Michael Trauner

Daniel Rosel

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