Trippier Paul

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Associate Professor

University of Nebraska Medical Center

United States

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About

Trippier Paul is an Associate Professor at the University of Nebraska Medical Center, USA. His research focuses on medicinal chemistry, specifically in the synthesis and biological characterization of novel inhibitors and activators for various enzymes and disease models. Recent publications include studies on functionalized benzo[d]imidazoles and aldo-keto reductase inhibitors, highlighting advancements in therapeutic approaches for conditions such as prostate cancer and neurodegenerative diseases.

Recent Grants

Grant: Open

UNMC Training Program in Alzheimer’s Disease and Related Dementias Drug Discovery

Open Date: 2022-06-01

Close Date: 2027-05-31

Grant: Close

Small Molecule Drug Discovery for CLN3 and CLN6 Disease

Open Date: 2021-09-20

Close Date: 2026-06-30

Grant: Close

Multifunctional Small Molecules for ALS Therapy

Open Date: 2020-10-01

Close Date: 2021-09-01

Grant: Close

AKR1C3 Inhibitors as Chemotherapeutic Potentiators

Open Date: 2019-01-01

Close Date: 2023-12-31

Grant: Close

Development and characterization of peptidomimetic small molecule activators of peptidase neurolysin for stroke therapy.

Open Date: 2018-09-15

Close Date: 2023-08-31

Articles (15)

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2025

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2025

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2024

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2024

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2023

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2023

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2023

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2023

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2022

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2022

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2021

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2021

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2021

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2020

Collaborators (8)

Paul S. Brookes

UNITED STATES

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Prof

UNMC

UNITED STATES

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Trippier Paul

Research Interests

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About

Recent Grants

Articles (15)

Discovery of Functionalized 1H-Benzo[d]imidazoles That Confer Protective Effects in a Phenotypic CLN3 Disease Patient-Derived iPSC Model

Synthesis and biological characterization of a 17β hydroxysteroid dehydrogenase type 10 (17β-HSD10) inhibitor

Imidazole Bioisostere Activators of Endopeptidase Neurolysin with Enhanced Potency and Metabolic Stability

Discovery of an Aldo-Keto reductase 1C3 (AKR1C3) degrader

Excellence in Medicinal Chemistry: Celebrating ACS Medicinal Chemistry Division (MEDI) Awards. A Call for Nominations

Excellence in Medicinal Chemistry: Celebrating ACS Medicinal Chemistry Division (MEDI) Awards. A Call for Nominations

Aldo-Keto Reductase 1C3 Inhibitor Prodrug Improves Pharmacokinetic Profile and Demonstrates In Vivo Efficacy in a Prostate Cancer Xenograft Model

Selective carbonic anhydrase IX and XII inhibitors based around a functionalized coumarin scaffold

The evolution of small molecule enzyme activators

Functionalized Allopurinols Targeting Amyloid-Binding Alcohol Dehydrogenase Rescue Aβ-Induced Mitochondrial Dysfunction

Access to Highly Strained Tricyclic Ketals Derived from Coumarins

Back to the Medicinal Chemistry Future

Patient-Derived Induced Pluripotent Stem Cell Models for Phenotypic Screening in the Neuronal Ceroid Lipofuscinoses

Discovery of Halogenated Benzothiadiazine Derivatives with Anticancer Activity**

Amide Bond Bioisosteres: Strategies, Synthesis, and Successes

Collaborators (8)

Paul S. Brookes

Vardan T. Karamyan

Shirisha Jonnalagadda

Trevor Penning

Lori Ferrins

Krishnaiah Maddeboina

Gunda Georg

DJ Murry

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