Tyler Beyett

Assistant Professor

Emory University

United States

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Articles (13)

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2024

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2024

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2024

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2024

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2024

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2022

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2022

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2022

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2022

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2022

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2022

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2022

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2021

Collaborators (10)

John Tesmer

Walther Professor in Cancer Structural Biology

Purdue University

UNITED STATES

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Anna Schmoker

Dana-Farber Cancer Institute

UNITED STATES

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Jason Tse

Life Science Research Professional 1

Stanford University School of Medicine

UNITED STATES

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Kunhua Li

UNITED STATES

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Florian Wittlinger

Eberhard Karls Universität Tübingen

GERMANY

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Varun Gadkari

Assistant Professor

University of Minnesota

UNITED STATES

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William Feng

Dana-Farber Cancer Institute

UNITED STATES

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Nathanael S. Gray

Stanford University

UNITED STATES

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David Scott

Dana-Farber Cancer Institute

UNITED STATES

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David Heppner

Assistant Professor

University at Buffalo

UNITED STATES

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Tyler Beyett

Research Interests

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Articles (13)

ZNL0325, a Pyrazolopyrimidine-Based Covalent Probe, Demonstrates an Alternative Binding Mode for Kinases

Structural Analysis of the Macrocyclic Inhibitor BI‐4020 Binding to EGFR Kinase

Molecular Bidents with Two Electrophilic Warheads as a New Pharmacological Modality

Linking ATP and allosteric sites to achieve superadditive binding with bivalent EGFR kinase inhibitors

A Constitutive EGFR Kinase Dimer to Study Inhibitor Pharmacology

Macrocyclization of Quinazoline-Based EGFR Inhibitors Leads to Exclusive Mutant Selectivity for EGFR L858R and Del19

An allosteric inhibitor against the therapy-resistant mutant forms of EGFR in non-small cell lung cancer

Quinazolinones as allosteric fourth-generation EGFR inhibitors for the treatment of NSCLC

Molecular basis for cooperative binding and synergy of ATP-site and allosteric EGFR inhibitors

Design of a “Two-in-One” Mutant-Selective Epidermal Growth Factor Receptor Inhibitor That Spans the Orthosteric and Allosteric Sites

A Novel HER2-Selective Kinase Inhibitor Is Effective in HER2 Mutant and Amplified Non–Small Cell Lung Cancer

Biochemical characterization of the interaction between KRAS and Argonaute 2

Comprehensive functional evaluation of variants of fibroblast growth factor receptor genes in cancer

Collaborators (10)

John Tesmer

Anna Schmoker

Jason Tse

Kunhua Li

Florian Wittlinger

Varun Gadkari

William Feng

Nathanael S. Gray

David Scott

David Heppner

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