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Viktor Brabec

Professor

Palacký University, Olomouc

Czech Republic

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Research Interests

Pharmaceutical Chemistry

70%

Materials Chemistry

30%

Cancer Therapy

40%

Cytotoxicity

40%

Supramolecular Chemistry

40%

Coordination Chemistry

30%

Metal Chemistry

30%

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Articles20

Phototoxicity of Half-Sandwich Rhodium(III) Complexes with Anthracene and Biphenyl Substituents toward Mammalian Cancer Cells and Multicellular Tumor Spheroids

Article Link

Year:

2025

Photoactivatable Cyclometalated Ir(III) Compound Penetrates the Blood-Brain Barrier in 3D Spheroidal and Advanced 3D Organoid Models of Inherently Resistant and Aggressive Brain Tumors

Article Link

Year:

2025

Excited-State Cis and Trans Pt(IV) Diamine Anticancer Complexes

Article Link

Year:

2025

A novel benzothiazole-1,2,3-triazole-based arene osmium(ii) complex as an effective rhabdomyosarcoma cancer stem cell agent

Article Link

Year:

2025

Multiaction Pt(IV) Prodrugs Releasing Cisplatin and Dasatinib Are Potent Anticancer and Anti-Invasive Agents Displaying Synergism between the Two Drugs

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Year:

2024

Photoactivatable, mitochondria targeting dppz iridium(III) complex selectively interacts and damages mitochondrial DNA in cancer cells

Article Link

Year:

2024

Novel 2-(5-Arylthiophen-2-yl)-benzoazole Cyclometalated Iridium(III) dppz Complexes Exhibit Selective Phototoxicity in Cancer Cells by Lysosomal Damage and Oncosis

Article Link

Year:

2024

New cyclometalated Ru(ii) polypyridyl photosensitizers trigger oncosis in cancer cells by inducing damage to cellular membranes

Article Link

Year:

2024

A Novel Substituted Benzo[g]quinoxaline-Based Cyclometalated Ru(II) Complex as a Biocompatible Membrane-Targeted PDT Colon Cancer Stem Cell Agent

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Year:

2024

Ni(II) Cylinders Damage DNA in Cancer Cells and Preferentially Bind Y‐Shaped DNA Three‐Way Junctions Blocking DNA Synthesis

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Year:

2024

Multitargeting Prodrugs that Release Oxaliplatin, Doxorubicin and Gemcitabine are Potent Inhibitors of Tumor Growth and Effective Inducers of Immunogenic Cell Death

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Year:

2023

Multitargeting Prodrugs that Release Oxaliplatin, Doxorubicin and Gemcitabine are Potent Inhibitors of Tumor Growth and Effective Inducers of Immunogenic Cell Death

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Year:

2023

The mechanism of antiproliferative activity of the oxaliplatin pyrophosphate derivative involves its binding to nuclear DNA in cancer cells

Article Link

Year:

2023

Metallohelices stabilize DNA three-way junctions and induce DNA damage in cancer cells

Article Link

Year:

2023

Ir(III) Compounds Containing a Terdentate Ligand Are Potent Inhibitors of Proliferation and Effective Antimetastatic Agents in Aggressive Triple-Negative Breast Cancer Cells

Article Link

Year:

2023

Palladium and Platinum Complexes of the Antimetabolite Fludarabine with Vastly Enhanced Selectivity for Tumour over Non-Malignant Cells

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Year:

2023

Platinum(IV) Derivatives of [Pt(1S,2S-diaminocyclohexane)(5,6-dimethyl-1,10-phenanthroline)] with Diclofenac Ligands in the Axial Positions: A New Class of Potent Multi-action Agents Exhibiting Selectivity to Cancer Cells

Article Link

Year:

2023

Cyclometalated Benzimidazole Osmium(II) Complexes with Antiproliferative Activity in Cancer Cells Disrupt Calcium Homeostasis

Article Link

Year:

2023

Triplex metallohelices have enantiomer-dependent mechanisms of action in colon cancer cells

Article Link

Year:

2023

Ruthenium(II)–Tris-pyrazolylmethane Complexes Inhibit Cancer Cell Growth by Disrupting Mitochondrial Calcium Homeostasis

Article Link

Year:

2022

Collaborators14

Nicola J. Rogers

University of Warwick

UNITED KINGDOM

Tomer Babu

University of Texas at Austin

UNITED STATES

Lorenzo Biancalana

University of Pisa

ITALY

Dan Gibson

ISRAEL

Janice R. Aldrich-Wright

University of Western Sydney

AUSTRALIA

Jakub Cervinka

Institute of Biophysics, Czech Academy of Sciences

CZECH REPUBLIC

Hannah Bridgewater

Coventry University

UNITED KINGDOM

Jose Ruiz

Professor of Inorganic Chemistry

Universidad de Murcia

SPAIN

Nicola Margiotta

Associate Professor

University of Bari Aldo Moro

ITALY

Valentina Gandin

University of Padova

ITALY

Thomas Mueller

Martin Luther University Halle-Wittenberg

GERMANY

P. Scott

University of Warwick

UNITED KINGDOM

Thomas Weber

GERMANY

James Coverdale

University of Birmingham

UNITED KINGDOM

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