Viktor Brabec

Professor

Palacký University, Olomouc

Czech Republic

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About

Viktor Brabec is a Professor at Palacký University in Olomouc, Czech Republic. His research primarily focuses on the phototoxicity of metal complexes and their applications in cancer therapy, as evidenced by his recent articles on various anticancer agents and their mechanisms. His work includes the study of Rhodium(III), Iridium(III), and Ru(II) complexes that target cancer cells and exploring their potential to penetrate biological barriers.

Articles (20)

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2025

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2025

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2025

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2025

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2024

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2024

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2024

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2024

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2024

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2024

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2023

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2023

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2023

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2023

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2023

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2023

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2023

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2023

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2023

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2022

Collaborators (14)

Nicola J. Rogers

University of Warwick

UNITED KINGDOM

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Tomer Babu

University of Texas at Austin

UNITED STATES

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Lorenzo Biancalana

University of Pisa

ITALY

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Dan Gibson

ISRAEL

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Janice R. Aldrich-Wright

University of Western Sydney

AUSTRALIA

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Jakub Cervinka

Institute of Biophysics, Czech Academy of Sciences

CZECH REPUBLIC

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Hannah Bridgewater

Coventry University

UNITED KINGDOM

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Jose Ruiz

Professor of Inorganic Chemistry

Universidad de Murcia

SPAIN

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Nicola Margiotta

Associate Professor

University of Bari Aldo Moro

ITALY

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Valentina Gandin

University of Padova

ITALY

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Thomas Mueller

Martin Luther University Halle-Wittenberg

GERMANY

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P. Scott

University of Warwick

UNITED KINGDOM

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Thomas Weber

GERMANY

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James Coverdale

University of Birmingham

UNITED KINGDOM

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Viktor Brabec

Research Interests

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About

Articles (20)

Phototoxicity of Half-Sandwich Rhodium(III) Complexes with Anthracene and Biphenyl Substituents toward Mammalian Cancer Cells and Multicellular Tumor Spheroids

Photoactivatable Cyclometalated Ir(III) Compound Penetrates the Blood-Brain Barrier in 3D Spheroidal and Advanced 3D Organoid Models of Inherently Resistant and Aggressive Brain Tumors

Excited-State Cis and Trans Pt(IV) Diamine Anticancer Complexes

A novel benzothiazole-1,2,3-triazole-based arene osmium(ii) complex as an effective rhabdomyosarcoma cancer stem cell agent

Multiaction Pt(IV) Prodrugs Releasing Cisplatin and Dasatinib Are Potent Anticancer and Anti-Invasive Agents Displaying Synergism between the Two Drugs

Photoactivatable, mitochondria targeting dppz iridium(III) complex selectively interacts and damages mitochondrial DNA in cancer cells

Novel 2-(5-Arylthiophen-2-yl)-benzoazole Cyclometalated Iridium(III) dppz Complexes Exhibit Selective Phototoxicity in Cancer Cells by Lysosomal Damage and Oncosis

New cyclometalated Ru(ii) polypyridyl photosensitizers trigger oncosis in cancer cells by inducing damage to cellular membranes

A Novel Substituted Benzo[g]quinoxaline-Based Cyclometalated Ru(II) Complex as a Biocompatible Membrane-Targeted PDT Colon Cancer Stem Cell Agent

Ni(II) Cylinders Damage DNA in Cancer Cells and Preferentially Bind Y‐Shaped DNA Three‐Way Junctions Blocking DNA Synthesis

Multitargeting Prodrugs that Release Oxaliplatin, Doxorubicin and Gemcitabine are Potent Inhibitors of Tumor Growth and Effective Inducers of Immunogenic Cell Death

Multitargeting Prodrugs that Release Oxaliplatin, Doxorubicin and Gemcitabine are Potent Inhibitors of Tumor Growth and Effective Inducers of Immunogenic Cell Death

The mechanism of antiproliferative activity of the oxaliplatin pyrophosphate derivative involves its binding to nuclear DNA in cancer cells

Metallohelices stabilize DNA three-way junctions and induce DNA damage in cancer cells

Ir(III) Compounds Containing a Terdentate Ligand Are Potent Inhibitors of Proliferation and Effective Antimetastatic Agents in Aggressive Triple-Negative Breast Cancer Cells

Palladium and Platinum Complexes of the Antimetabolite Fludarabine with Vastly Enhanced Selectivity for Tumour over Non-Malignant Cells

Platinum(IV) Derivatives of [Pt(1S,2S-diaminocyclohexane)(5,6-dimethyl-1,10-phenanthroline)] with Diclofenac Ligands in the Axial Positions: A New Class of Potent Multi-action Agents Exhibiting Selectivity to Cancer Cells

Cyclometalated Benzimidazole Osmium(II) Complexes with Antiproliferative Activity in Cancer Cells Disrupt Calcium Homeostasis

Triplex metallohelices have enantiomer-dependent mechanisms of action in colon cancer cells

Ruthenium(II)–Tris-pyrazolylmethane Complexes Inhibit Cancer Cell Growth by Disrupting Mitochondrial Calcium Homeostasis

Collaborators (14)

Nicola J. Rogers

Tomer Babu

Lorenzo Biancalana

Dan Gibson

Janice R. Aldrich-Wright

Jakub Cervinka

Hannah Bridgewater

Jose Ruiz

Nicola Margiotta

Valentina Gandin

Thomas Mueller

P. Scott

Thomas Weber

James Coverdale

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