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Vittorio Canale

Assistant Professor

Jagiellonian University

Poland

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Research Interests

Pharmacology

90%

Pharmaceutical Chemistry

90%

Neuropharmacology

50%

G Protein-coupled Receptor

50%

Heterocyclic Chemistry

40%

Total Synthesis

20%

Endocannabinoid

20%

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Articles17

New Quipazine Derivatives Active Against Drug-Resistant Oncogenic Helicobacter pylori Strains with Biofilm

Article Link

Year:

2025

Correction: Compound PZ-1262, a 4-isoquinoline-sulfonamide analog of Brexpiprazole, produces potential antidepressant, anxiolytic and procognitive effects in rodent models

Article Link

Year:

2025

Compound PZ-1262, a 4-isoquinoline-sulfonamide analog of Brexpiprazole, produces potential antidepressant, anxiolytic and procognitive effects in rodent models

Article Link

Year:

2025

Current development in sulfonamide derivatives to enable CNS-drug discovery

Article Link

Year:

2025

Comparison of greenness and whiteness of selected mechanochemical and solution-based reactions using a new RGBsynt model

Article Link

Year:

2025

Improving Activity of New Arylurea Agents against Multidrug-Resistant and Biofilm-Producing Staphylococcus epidermidis

Article Link

Year:

2024

The Constitutive Activity of Spinal 5-HT6 Receptors Contributes to Diabetic Neuropathic Pain in Rats

Article Link

Year:

2023

Design and synthesis of novel arylurea derivatives of aryloxy(1-phenylpropyl) alicyclic diamines with antimicrobial activity against multidrug-resistant Gram-positive bacteria

Article Link

Year:

2023

Multistep Mechanochemical Synthesis of PZ-1190, a Multitarget Antipsychotic Agent

Article Link

Year:

2023

1-(Arylsulfonyl-isoindol-2-yl)piperazines as 5-HT6R Antagonists: Mechanochemical Synthesis, In Vitro Pharmacological Properties and Glioprotective Activity

Article Link

Year:

2022

Design, Sustainable Synthesis and Biological Evaluation of a Novel Dual α2A/5-HT7 Receptor Antagonist with Antidepressant-Like Properties

Article Link

Year:

2021

2-Phenyl-1H-pyrrole-3-carboxamide as a New Scaffold for Developing 5-HT6 Receptor Inverse Agonists with Cognition-Enhancing Activity

Article Link

Year:

2021

Novel mutual prodrug of 5-fluorouracil and heme oxygenase-1 inhibitor (5-FU/HO-1 hybrid): design and preliminary in vitro evaluation

Article Link

Year:

2021

Imidazopyridine-Based 5-HT6 Receptor Neutral Antagonists: Impact of N1-Benzyl and N1-Phenylsulfonyl Fragments on Different Receptor Conformational States

Article Link

Year:

2021

Sustainable Synthesis of a Potent and Selective 5-HT7 Receptor Antagonist Using a Mechanochemical Approach

Article Link

Year:

2020

A dual-acting 5-HT6 receptor inverse agonist/MAO-B inhibitor displays glioprotective and pro-cognitive properties

Article Link

Year:

2020

mTOR activation by constitutively active serotonin6 receptors as new paradigm in neuropathic pain and its treatment

Article Link

Year:

2020

Collaborators14

Agnieszka Nikiforuk

Maj Institute of Pharmacology Polish Academy of Sciences

POLAND

Agata Kuziak

Jagiellonian University

POLAND

Valeria Ciaffaglione

ITALY

Frédéric Lamaty

University of Montpellier

FRANCE

Thomas Brzozowski

profesor

Uniwersytet Jagiellonski Collegium Medicum

POLAND

Séverine Chaumont-Dubel

Assistant professor

University of Montpellier

FRANCE

Christine Courteix

Professor of Physiology

Université Clermont Auvergne

FRANCE

Karolina Klesiewicz

Uniwersytet Jagiellonski Collegium Medicum

POLAND

Andrzej Bojarski

Head of the department

Institute of Pharmacology

POLAND

Paweł Zajdel

professor

Uniwersytet Jagiellonski Collegium Medicum

POLAND

Elżbieta Pękala

Jagiellonian University Medical College

POLAND

Elżbieta Karczewska

Associate professor / PhD, DSc

Uniwersytet Jagiellonski Collegium Medicum

POLAND

Xavier Bantreil

Associate Professor (HDR)

Institut des Biomolécules Max Mousseron

FRANCE

Philippe Marin

University of Montpellier

FRANCE

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Vittorio Canale

Assistant Professor

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Research Interests

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Articles17

New Quipazine Derivatives Active Against Drug-Resistant Oncogenic <i>Helicobacter pylori</i> Strains with Biofilm

Correction: Compound PZ-1262, a 4-isoquinoline-sulfonamide analog of Brexpiprazole, produces potential antidepressant, anxiolytic and procognitive effects in rodent models

Compound PZ-1262, a 4-isoquinoline-sulfonamide analog of Brexpiprazole, produces potential antidepressant, anxiolytic and procognitive effects in rodent models

Current development in sulfonamide derivatives to enable CNS-drug discovery

Comparison of greenness and whiteness of selected mechanochemical and solution-based reactions using a new RGBsynt model

Improving Activity of New Arylurea Agents against Multidrug-Resistant and Biofilm-Producing Staphylococcus epidermidis

The Constitutive Activity of Spinal 5-HT<sub>6</sub> Receptors Contributes to Diabetic Neuropathic Pain in Rats

Design and synthesis of novel arylurea derivatives of aryloxy(1-phenylpropyl) alicyclic diamines with antimicrobial activity against multidrug-resistant Gram-positive bacteria

Multistep Mechanochemical Synthesis of PZ-1190, a Multitarget Antipsychotic Agent

1-(Arylsulfonyl-isoindol-2-yl)piperazines as 5-HT<sub>6</sub>R Antagonists: Mechanochemical Synthesis, In Vitro Pharmacological Properties and Glioprotective Activity

Design, Sustainable Synthesis and Biological Evaluation of a Novel Dual α2A/5-HT7 Receptor Antagonist with Antidepressant-Like Properties

2-Phenyl-1H-pyrrole-3-carboxamide as a New Scaffold for Developing 5-HT6 Receptor Inverse Agonists with Cognition-Enhancing Activity

Novel mutual prodrug of 5-fluorouracil and heme oxygenase-1 inhibitor (5-FU/HO-1 hybrid): design and preliminary in vitro evaluation

Imidazopyridine-Based 5-HT6 Receptor Neutral Antagonists: Impact of N1-Benzyl and N1-Phenylsulfonyl Fragments on Different Receptor Conformational States

Sustainable Synthesis of a Potent and Selective 5-HT7 Receptor Antagonist Using a Mechanochemical Approach

A dual-acting 5-HT6 receptor inverse agonist/MAO-B inhibitor displays glioprotective and pro-cognitive properties

mTOR activation by constitutively active serotonin6 receptors as new paradigm in neuropathic pain and its treatment

Collaborators14

Agnieszka Nikiforuk

Agata Kuziak

Valeria Ciaffaglione

Frédéric Lamaty

Thomas Brzozowski

Séverine Chaumont-Dubel

Christine Courteix

Karolina Klesiewicz

Andrzej Bojarski

Paweł Zajdel

Elżbieta Pękala

Elżbieta Karczewska

Xavier Bantreil

Philippe Marin

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