William Bush

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Associate Professor

Case Western Reserve University

United States

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About

William Bush is an Associate Professor at Case Western Reserve University in the United States. His research primarily focuses on Alzheimer's disease, heritability estimates, genetic factors, and the impact of dietary components on neurodegenerative conditions. He has authored numerous articles exploring the genetic architecture of cognitive resilience, the role of omega-6-PUFA consumption, and the association of various genes with Alzheimer’s and related disorders.

Recent Grants

Grant: Close

The Alzheimer Disease Sequence Analysis Collaborative

Open Date: 2018-09-30

Close Date: 2023-08-31

Grant: Close

An Atlas of Clinical Associations mapping to Variants within Protein Structures

Open Date: 2018-09-30

Close Date: 2021-06-30

Articles (16)

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2025

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2021

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2021

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2021

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2021

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2021

Collaborators (16)

Michael Freeman

Associate Professor, Pediatric Nephrology

Penn State Health Milton S Hershey Medical Center

UNITED STATES

William Bush

Research Interests

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About

Recent Grants

Articles (16)

Country-level incidence of Alzheimer disease and related dementias is associated with increased omega-6-PUFA consumption

Alzheimer disease is (sometimes) highly heritable: Drivers of variation in heritability estimates for binary traits, a systematic review

Brain and blood transcriptome-wide association studies identify five novel genes associated with Alzheimer's disease

NIAGADS Alzheimer's GenomicsDB: A resource for exploring Alzheimer's disease genetic and genomic knowledge

Sex-Biased Associations of Circulating Ferroptosis Inhibitors with Reduced Lipid Peroxidation and Better Neurocognitive Performance in People with HIV

HORNET: tools to find genes with causal evidence and their regulatory networks using eQTLs

Sex differences in the genetic architecture of cognitive resilience to Alzheimer's disease.

A Rare Germline HOXB13 Variant Contributes to Risk of Prostate Cancer in Men of African Ancestry.

Higher CSF Ferritin Heavy-Chain (Fth1) and Transferrin Predict Better Neurocognitive Performance in People with HIV

Genetically regulated expression in late-onset Alzheimer’s disease implicates risk genes within known and novel loci

A Participant-Centered Approach to Understanding Risks and Benefits of Participation in Research Informed by the Kidney Precision Medicine Project.

A Haptoglobin Exon Copy Number Variant Associates With HIV-Associated Neurocognitive Impairment in European and African-Descent Populations.

Large-scale sequencing studies expand the known genetic architecture of Alzheimer's disease.

Interaction between <i>M. tuberculosis</i> Lineage and Human Genetic Variants Reveals Novel Pathway Associations with Severity of TB.

Replication of European hypertension associations in a case-control study of 9,534 African Americans.

Methylome-wide Analysis Reveals Epigenetic Marks Associated With Resistance to Tuberculosis in Human Immunodeficiency Virus-Infected Individuals From East Africa.

Collaborators (16)

Michael Freeman

Rafal Sobota

Ian M. Thompson

Catherine M. Stein

Garry Nolan

Mark V Williams

Catherine Kaczorowski

Asha Kallianpur

Adam Naj

Ulysses Balis

Ujani Hazra

Giuseppe Tosto

Pavel Kuksa

Yuk Yee Leung

David Samuels

Anita DeStefano

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