William Klunk

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Distinguished Professor

University of Pittsburgh

United States

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About

William Klunk is a Distinguished Professor at the University of Pittsburgh, USA. His research primarily focuses on Alzheimer's disease, specifically investigating the relationships between β-amyloid accumulation, tau pathology, and microglial activation. Recent publications highlight his work on biomarker profiles and their implications for dementia in various populations, including individuals with Down syndrome.

Recent Grants

Grant: Close

Amyloid-Lowering Small Molecule AB-Binding Agents in AD

Open Date: 2006-09-15

Close Date: 2013-05-31

Grant: Close

IN VIVO PIB PET AMYLOID IMAGING: NORMALS, MCI &DEMENTIA

Open Date: 2005-05-15

Close Date: 2015-04-30

Grant: Close

AMYLOID PATHOLOGY AND COGNITION IN NORMAL ELDERLY

Open Date: 2005-03-01

Close Date: 2015-02-28

Grant: Close

NATURAL HISTORY OF AMYLOID DEPOSITION FAMILIAL AD

Open Date: 2005-01-01

Close Date:

Grant: Close

PET TRACERS TO MONITOR VACCINE AND IMMUNE THERAPY FOR AD

Open Date: 2001-09-30

Close Date: 2007-07-31

Articles (20)

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2021

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2021

Collaborators (15)

Thomas Karikari

Assistant Professor of Psychiatry

University of Pittsburgh

UNITED STATES

William Klunk

Research Interests

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About

Recent Grants

Articles (20)

Association Between β-Amyloid Accumulation and Incident Dementia in Individuals 80 Years or Older Without Dementia

APOE ε4 associates with microglial activation independently of Aβ plaques and tau tangles

Astrocyte reactivity influences amyloid-β effects on tau pathology in preclinical Alzheimer's disease.

Brain network decoupling with increased serum neurofilament and reduced cognitive function in Alzheimer’s disease

Comparison of amyloid burden in individuals with Down syndrome versus autosomal dominant Alzheimer's disease: a cross-sectional study

APOEε4 potentiates amyloid β effects on longitudinal tau pathology.

AT(N) biomarker profiles and Alzheimer's disease symptomology in Down syndrome

Blood-brain barrier integrity impacts the use of plasma amyloid-β as a proxy of brain amyloid-β pathology

Characterizing the emergence of amyloid and tau burden in Down syndrome

White matter microstructure associations to amyloid burden in adults with Down syndrome

Biomarker clustering in autosomal dominant Alzheimer's disease

Physical activity and cognitive and imaging biomarkers of Alzheimer's disease in down syndrome

Peripheral inflammatory biomarkers predict the deposition and progression of amyloid-β in cognitively unimpaired older adults

A multi-scanner neuroimaging data harmonization using RAVEL and ComBat

Alzheimer’s disease pathology in a community-based sample of older adults without dementia: The MYHAT neuroimaging study

Amyloid and Tau Pathology Associations With Personality Traits, Neuropsychiatric Symptoms, and Cognitive Lifestyle in the Preclinical Phases of Sporadic and Autosomal Dominant Alzheimer's Disease

An Effect of Education on Memory-Encoding Activation in Subjective Cognitive Decline

Characterization of point-spread function specification error on Geometric Transfer Matrix partial volume correction in [<sup>11</sup>C]PiB amyloid imaging

Comparing amyloid-β plaque burden with antemortem PiB PET in autosomal dominant and late-onset Alzheimer disease

Comparing pathological risk factors for dementia between cognitively normal japanese and americans

Collaborators (15)

Thomas Karikari

Colin L. Masters

Firoza Zubeida Lussier

Sarah Berman

John Morris

Nick Fox

Matthew Zammit

Christopher Rowe

Tharick A. Pascoal

Randall Bateman

Carlos Cruchaga

Akira Sekikawa

Davneet Minhas

Nelly Joseph-Mathurin

Chester Mathis

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