Wolfgang Sippl

Professor

Martin Luther University Halle-Wittenberg

Germany

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Professor Wolfgang Sippl is affiliated with Martin Luther Universität Halle-Wittenberg in Germany. His research primarily focuses on medicinal chemistry, specifically in the areas of HDAC inhibitors, PROTACs, and molecular dynamics simulations. Recent publications include studies on the design of novel therapeutic compounds targeting various cancer-related mechanisms. His work integrates in silico modeling with practical applications in drug development.

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2025

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2022

Collaborators (7)

Matthias Schiedel

Professor

Technische Universität Braunschweig

GERMANY

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Oliver H. Krämer

GERMANY

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Matthias Wirth

Charité Universitätsmedizin Berlin Campus Benjamin Franklin

GERMANY

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Michael Linnebacher

GERMANY

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Dina Robaa

Martin Luther University Halle-Wittenberg

GERMANY

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Mohamed Abdelsalam

Martin Luther University Halle-Wittenberg

GERMANY

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Manfred Jung

Professor for Pharmaceutical Chemistry, www.jungm.de

University of Freiburg

GERMANY

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Wolfgang Sippl

Research Interests

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About

Articles (20)

Efficient Crystallization of Apo Sirt2 for Small-Molecule Soaking and Structural Analysis of Ligand Interactions

In silico screening of a designed focused chemical space identifies novel alkyl hydrazides as potent HDAC11 inhibitors

HADDOCK-Guided modeling and molecular simulations of cereblon-based ternary complexes: Development of novel PROTACs for Ataxia telangiectasia and RAD3-Related (ATR) kinase

CCR4-NOT Transcription Complex Subunit 7 (CNOT7) Protein and Leukocyte-Associated Immunoglobulin-like Receptor-1 in Breast Cancer Progression: Clinical Mechanistic Insights and In Silico Therapeutic Potential

Ternary Complex Modeling, Induced Fit Docking and Molecular Dynamics Simulations as a Successful Approach for the Design of VHL‐Mediated PROTACs Targeting the Kinase FLT3

A Facile and Rapid Method for Synthesizing Indole–Chalcone Hybrids

Predicting fragment binding modes using customized Lennard-Jones potentials in short molecular dynamics simulations

iNOS/PGE2 inhibitors as a novel template for analgesic/anti‐inflammatory activity: Design, synthesis, in vitro biological activity and docking studies

Aromatic Amino Acid Hydroxylases as Off-Targets of Histone Deacetylase Inhibitors

Development of new pyrazoles as class I HDAC inhibitors: Synthesis, molecular modeling, and biological characterization in leukemia cells

NOXA Accentuates Apoptosis Induction by a Novel Histone Deacetylase Inhibitor

Application of Ligand- and Structure-Based Prediction Models for the Design of Alkylhydrazide-Based HDAC3 Inhibitors as Novel Anti-Cancer Compounds

Editorial for Special Issue—“Early-Stage Drug Discovery: Advances and Challenges”

Molecular docking, molecular dynamics simulations and in vitro screening reveal cefixime and ceftriaxone as GSK3β covalent inhibitors

N4-(2-Amino-4-fluorophenyl)-N1-(3-{2-[2-(3-{[2-(2,6-dioxo-3-piperidyl)-1,3-dioxoisoindolin-4-yl]amino}propoxy)ethoxy]ethoxy}propyl)terephthalamide

Small Changes Make the Difference for SIRT2: Two Different Binding Modes for 3-Arylmercapto-Acylated Lysine Derivatives

Development and Validation of [3H]OF-NB1 for Preclinical Assessment of GluN1/2B Candidate Drugs

Design, Synthesis and Biological Characterization of Histone Deacetylase 8 (HDAC8) Proteolysis Targeting Chimeras (PROTACs) with Anti-Neuroblastoma Activity

Uncovering Robust Delactoylase and Depyruvoylase Activities of HDAC Isoforms

Development of New Inhibitors of HDAC1–3 Enzymes Aided by In Silico Design Strategies

Collaborators (7)

Matthias Schiedel

Oliver H. Krämer

Matthias Wirth

Michael Linnebacher

Dina Robaa

Mohamed Abdelsalam

Manfred Jung

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