Xiao-bo Zhong

Professor

University of Connecticut

United States

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Professor Xiao-bo Zhong is a faculty member at the University of Connecticut, USA. His research focuses on drug metabolism, highlighting the effects of various biological factors on the efficacy of small interfering RNA drugs and antisense oligonucleotide therapies. Recent publications include investigations into intracellular fatty acid levels, long noncoding RNAs, and their implications for liver health and drug response.

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2022

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2022

Collaborators (17)

André Gerber

Professor

University of Surrey

UNITED KINGDOM

Xiao-bo Zhong

Research Interests

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Articles (23)

Intracellular fatty acid levels differentially impact target silencing by FDA-approved siRNA drugs

Visualization of CYP3A4 expression at both mRNA and protein levels simultaneously at single cell resolution in various conditions using RNAscope combined with immunofluorescence

The ASO drug olezarsen targets familial chylomicronemia syndrome

Unraveling the Regulatory Impact of LncRNA Hnf1aos1 on Hepatic Homeostasis in Mice

Impact on efficacy of target reduction of two FDA-approved ASO drugs by intracellular glucose levels in in vitro cell models

Role of HNF4A-AS1/HNRNPC-mediated HNF4A ubiquitination protection against ritonavir-induced hepatotoxicity

Scientific Contributions to Drug Metabolism by Dr. Edward T. Morgan, the Recipient of the Bernard B. Brodie Award in Drug Metabolism and Disposition in 2024–Editorial

Correlations of LncRNA HNF4A-AS1 Alternative Transcripts with Liver Diseases and Drug Metabolism

Special Section on Mechanisms of Drug Metabolism in Acetaminophen-Induced Hepatotoxicity—Editorial

Special Section on Cytochrome P450 Enzymes in Toxicology and as Drug Targets—Editorial

Identification and Functional Characterization of Alternative Transcripts of LncRNA HNF1A-AS1 and Their Impacts on Cell Growth, Differentiation, Liver Diseases, and in Response to Drug Induction

The 2024 Nobel Prize in Physiology or Medicine: microRNA Takes Center Stage

50th Anniversary Celebration Collection Special Section on New and Emerging Areas and Technologies in Drug Metabolism and Disposition, Part II—Editorial

The Non-Coding RNA Journal Club: Highlights on Recent Papers—12

Special Section on New and Emerging Areas and Technologies in Drug Metabolism and Disposition, Part I–Editorial

ASO drug Qalsody (tofersen) targets amyotrophic lateral sclerosis

Special Section on Mechanism-Based Predictive Methods in Drug Discovery and Development—Editorial

Special Section on Perspectives on Drug Metabolism and Disposition, Part II—Editorial

Epigenetic Mechanisms Contribute to Intraindividual Variations of Drug Metabolism Mediated by Cytochrome P450 Enzymes

Special Section on Drug Metabolism and Precision Medicine—Editorial

Nephrotoxicity of marketed antisense oligonucleotide drugs

Nedosiran, a Candidate siRNA Drug for the Treatment of Primary Hyperoxaluria: Design, Development, and Clinical Studies

Special Section on Pharmacokinetics and ADME of Biological Therapeutics–Editorial

Collaborators (17)

André Gerber

Shizuka Uchida

Aiming Yu

Johanna DiStefano

Alessio Naccarati

Jing Jin

Yoh Asahi

Mirolyuba Ilieva

Ling Yang

Ajay Goel

Barbara Pardini

Michael Ladomery

Manuela Ferracin

Alexander Serganov

Leandro Castellano

Nicholas Delihas

Simon Conn

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