Xiaohui (Frank) Zhang

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United States

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About

Xiaohui (Frank) Zhang is a Professor at the University of Massachusetts Amherst College of Engineering. His research areas include biophysics, biomechanics, and nanotechnology, with a focus on viral interactions and mechanisms related to various diseases. Recent publications explore the mechanical properties of virus-like particles, cellular adhesion measurements, and the role of glycoproteins in viral attachment and activation pathways.

Recent Grants

Grant: Close

Mechanism underlying cofactor-dependent proteolysis of von Willebrand Factor

Open Date: 2022-02-01

Close Date: 2026-01-31

Grant: Close

Mechanical regulation of von Willebrand factor

Open Date: 2021-09-01

Close Date: 2025-06-30

Grant: Close

Biophysical characterization of SARS-CoV-2 spike protein - receptor interactions

Open Date: 2021-07-06

Close Date: 2023-06-30

Grant: Close

Bioinspired, Single-molecule Based Shear Switchable Nanomaterials

Open Date: 2020-06-01

Close Date: 2023-05-31

Grant: Close

Single-cell analysis of endothelial mechanotransduction mediated by endothelial surface glycocalyx

Open Date: 2020-05-01

Close Date: 2023-04-30

Articles (13)

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2025

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2024

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2024

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2023

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2023

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2023

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2022

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2022

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2022

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2021

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2021

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2021

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2021

Collaborators (4)

Edmund Webb III

Associate Professor

Lehigh University

UNITED STATES

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Renhao Li

Professor

Emory University School of Medicine

UNITED STATES

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Jonas Emsley

professor of macromolecular crystallography

University of Nottingham

UNITED KINGDOM

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Wendy J. Maury

Iowa State University

UNITED STATES

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Xiaohui (Frank) Zhang

Research Interests

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About

Recent Grants

Articles (13)

Nanoscale Mechanical and Morphological Characterization of Ebolavirus-like Particles: Implications for Therapeutic Development

Biomechanics Model to Characterize Atomic Force Microscopy-Based Virus–Host Cell Adhesion Measurements

Nano-Biomechanical Investigation of Phosphatidylserine-Mediated Ebola Viral Attachment via Human Gas6 and Axl

Type 2B von Willebrand disease mutations differentially perturb autoinhibition of the A1 domain

Biophysical investigation of interactions between SARS‐CoV‐2 spike protein and neuropilin‐1

Penetration of Cell Surface Glycocalyx by Enveloped Viruses Is Aided by Weak Multivalent Adhesive Interaction

Autoinhibitory module underlies species difference in shear activation of von Willebrand factor

Desialylation of O‐glycans activates von Willebrand factor by destabilizing its autoinhibitory module

Contribution of the von Willebrand factor/ADAMTS13 imbalance to COVID-19 coagulopathy

Activation of von Willebrand factor via mechanical unfolding of its discontinuous autoinhibitory module.

Predicting pathological von Willebrand factor unraveling in elongational flow

Biophysical characterization of lynx‐nicotinic receptor interactions using atomic force microscopy

Biomechanical characterization of SARS-CoV-2 spike RBD and human ACE2 protein-protein interaction

Collaborators (4)

Edmund Webb III

Renhao Li

Jonas Emsley

Wendy J. Maury

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