Jonas Emsley

professor of macromolecular crystallography

University of Nottingham

United Kingdom

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Jonas Emsley is a professor of macromolecular crystallography at the University of Nottingham in the United Kingdom. His research focuses on the structural biology of proteins involved in coagulation, including recent studies on the contact system proteins and the activation mechanisms of zymogen factor XII. He has contributed significantly to the understanding of various clotting factors and their interactions, as evidenced by his numerous publications in the field.

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2025

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2021

Collaborators (19)

Fadi Soukarieh

Lecturer in Medicinal Chemistry

University of Sheffield

UNITED KINGDOM

Jonas Emsley

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Articles (20)

A model of zymogen factor XII: insights into protease activation

Structure and interactions of the proteins from the contact system

Crystal structure of coagulation factor XII N-terminal domains 1–5

Discovery of α-Amidobenzylboronates as Highly Potent Covalent Inhibitors of Plasma Kallikrein.

Conformational activation and inhibition of von Willebrand factor by targeting its autoinhibitory module

Design, Synthesis, and Evaluation of New 1<i>H</i>-Benzo[<i>d</i>]imidazole Based PqsR Inhibitors as Adjuvant Therapy for <i>Pseudomonas aeruginosa</i> Infections.

Aptamer BT200 blocks interaction of K1405-1408 in the VWF-A1 domain with macrophage LRP1

Epithelial Interleukin-1 Receptor-Like-1 Activation Is Contingent on Interleukin-33 Isoforms and Asthma-Related Receptor Variation.

Structures of factor XI and prekallikrein bound to domain 6 of high–molecular weight kininogen reveal alternate domain 6 conformations and exosites

Plasma Kallikrein as a Forgotten Clotting Factor

Characterizing the binding of glycoprotein VI with nanobody 35 reveals a novel monomeric structure of glycoprotein VI where the conformation of D1+D2 is independent of dimerization

High molecular weight kininogen interactions with the homologs prekallikrein and factor XI: importance to surface-induced coagulation.

Ubiquitin-specific protease 11 structure in complex with an engineered substrate mimetic reveals a molecular feature for deubiquitination selectivity.

Inherited ADAMTS13 mutations associated with Thrombotic Thrombocytopenic Purpura: a short review and update.

An update on factor XII-driven vascular inflammation.

Design and Evaluation of New Quinazolin-4(3<i>H</i>)-one Derived PqsR Antagonists as Quorum Sensing Quenchers in <i>Pseudomonas aeruginosa</i>.

Factor VIII/VWF complex caught on camera

Activation of von Willebrand factor via mechanical unfolding of its discontinuous autoinhibitory module.

Crystal structure of ADAMTS13 CUB domains reveals their role in global latency

Thrombin in the Activation of the Fluid Contact Phase in Patients with Hereditary Angioedema Carrying the F12 P.Thr309Lys Variant.

Collaborators (19)

Fadi Soukarieh

Henri Spronk

Mark Thomas

Natalie J. Jooss

Roger Preston

James T. B. Crawley

Steve P. Watson

Helen Philippou

Nigel Key

David Gailani

Joanne Clark

Alexandre Slater

Roger Levesque

Barrie Kellam

Manuel Romero Bernardez

Xiaohui (Frank) Zhang

Renhao Li

Eleyna Martin

Natalie Poulter

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